Association of rheumatoid factor production with FcγRIIIa polymorphism in Taiwanese rheumatoid arthritis
Association of rheumatoid factor production with FcγRIIIa polymorphism in Taiwanese rheumatoid arthritis
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DOI：
10.1111/j.1365-2249.2006.03021.x
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发表时间：
2006-04-01
影响因子：
4.6
通讯作者：
Luo, SF
中科院分区：
文献类型：
--
作者：
Chen, JY;Wang, CM;Luo, SF
Fc γ 受体 (Fc γ R) 通过免疫复合物刺激和促炎细胞因子的产生影响炎症性关节炎的发展。使用等位基因特异性聚合酶链反应 (PCR) 对 212 名类风湿性关节炎 (RA) 患者和 371 名健康对照受试者的 Fc gamma RIIa、Fc gamma R Iota Iota Iota a 和 FcR gamma IIIb 多态性进行了基因分型。在 RA 患者和健康对照受试者之间未发现 Fc gamma RIIa H/R131、Fc gamma RIIIa F/V158 和 Fc gamma RIIIb NA1/NA2 的分布存在显着偏斜。然而，在类风湿因子 (RF) 阳性与 RF 阴性 RA 患者之间观察到 Fc gamma RIIIa F/V158 多态性的显着偏态分布 (P = 0.01)。与 Fc gamma RIIIa V158 等位基因相比，低亲和力 Fc gamma RIIIa F158 等位基因似乎在 RF 产生中具有保护作用（P = 0.004；OR = 0.485；95% CI：0.293-0.803）。与 RF 阳性患者相比，RF 阴性的 RA 患者中 Fc gamma RIIIa F/F158 的频率较高（FF158 与 FV158 + VV158；P = 0.002；OR = 0.372；95% CI：0.194-0.713）。此外，未发现 Fc gamma RIIa H/R131、Fc gamma Rho IIIa F/V158 和 Fc gamma RIIIb NA1/NA2 多态性与其他临床参数之间存在关联。这项研究的结果表明，三种激活性 Fc gamma Rs 多态性与 RA 缺乏关联，但 Fc gamma IIIa F/V158 多态性可能会影响台湾 RA 患者的 RF 产生和 IgG RF 免疫复合物处理。
Fc gamma receptors (Fc gamma R) impact upon the development of inflammatory arthritis through immune complex stimulation and proinflammatory cytokine production. Fc gamma RIIa, Fc gamma R Iota Iota Iota a and FcR gamma IIIb polymorphisms were genotyped in 212 rheumatoid arthritis (RA) patients and 371 healthy control subjects using an allelic-specific polymerase chain reaction (PCR). No significant skewing in the distribution of Fc gamma RIIa H/R131, Fc gamma RIIIa F/V158 and Fc gamma RIIIb NA1/NA2 was found between RA patients and healthy control subjects. However, a significant skewing distribution of the Fc gamma RIIIa F/V158 polymorphism was observed between rheumatoid factor (RF)-positive versus RF-negative RA patients (P = 0.01). The low-affinity Fc gamma RIIIa F158 allele seems to have a protective role in RF production, in comparison with the Fc gamma RIIIa V158 allele (P = 0.004; OR = 0.485; 95% CI: 0.293-0.803). A high frequency of Fc gamma RIIIa F/F158 was identified in RA patients with negative RF compared with RF-positive patients (for FF158 versus FV158 + VV158; P = 0.002; OR = 0.372; 95% CI: 0.194-0.713). In addition, no association was found between Fc gamma RIIa H/R131, Fc gamma Rho IIIa F/V158 and Fc gamma RIIIb NA1/NA2 polymorphisms and other clinical parameters. The results of this study suggest that three activating Fc gamma Rs polymorphisms lack association with RA but Fc gamma IIIa F/V158 polymorphism may influence RF production and IgG RF immune complex handling in Taiwanese RA patients.