Prevalence of Age-Related Macular Degeneration in an Elderly Urban Chinese Population in China: The Jiangning Eye Study
Prevalence of Age-Related Macular Degeneration in an Elderly Urban Chinese Population in China: The Jiangning Eye Study
复制标题
中国城市老年人群中年龄相关性黄斑变性的患病率：江宁眼科研究。
DOI：
10.1167/iovs.14-14899
复制
发表时间：
2014-10-01
影响因子：
4.4
通讯作者：
Zhao, Peiquan
中科院分区：
文献类型：
--
作者：
Ye, Hehua;Zhang, Qi;Zhao, Peiquan
目的.描述中国城市老年人群中AMD的患病率。采用整群随机抽样的方法，对上海市静安区江宁路街道50岁以上的居民进行了一项基于人群的横断面研究。所有参与者在2012年11月至2013年2月期间接受了标准化访谈和全面的眼科检查，包括双眼的数字视网膜摄影和光谱域光学相干断层扫描（OCT）检查。经过培训的分级人员根据威斯康星州AMD相关黄斑病变分级系统的修改版本评估AMD病变的存在和严重程度。在参与的2044例受试者中（82.5%的应答率），2005例的眼底照片和OCT结果质量足以对AMD体征进行分级。早期和晚期AMD分别出现在206例（10.3%）和23例（1.1%）参与者中。年龄标准化后，中国50岁以上人群中早期AMD的患病率为9.5%（95%CI，8.2-10.8），晚期AMD的患病率为1.0%（95%CI，0.51 ~ 10.5）。在中国城市样本中，早期和晚期AMD的患病率高于北京和邯郸研究报告的患病率。黄斑变性在中国大陆城市老年人群中非常普遍。
PURPOSE. To describe the prevalence of AMD in an elderly urban Chinese population in China.METHODS. A population-based, cross-sectional study was conducted using a cluster random sample of residents aged 50 years or older living in the Jiangning Road Subdistrict, Jing'an District, Shanghai, China. All participants underwent a standardized interview and comprehensive eye examinations, including digital retinal photography and spectral-domain optical coherence tomography (OCT) examinations of both eyes between November 2012 and February 2013. Trained graders assessed the presence and severity of AMD lesions based on a modified version of the Wisconsin Age-Related Maculopathy Grading System.RESULTS. Of the 2044 subjects who participated (82.5% response rate), 2005 had fundus photographs and OCT results of sufficient quality for grading of AMD signs. Early and late AMD were present in 206 (10.3%) and 23 (1.1%) participants, respectively. After age standardization, the prevalence of early AMD in Chinese persons aged 50 years or older was 9.5% (95% confidence interval [CI], 8.2-10.8) and that of late AMD was 1.0% (95% CI, 0.51.5).CONCLUSIONS. The prevalence of early and late AMD in this urban Chinese sample was higher than that reported in the Beijing and Handan studies. Age-related macular degeneration is highly prevalent among the elderly urban Chinese population in mainland China.