Cardiac regeneration and stem cell therapy.
Cardiac regeneration and stem cell therapy.
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DOI：
10.1097/mot.0b013e32830fdfc4
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发表时间：
2008-10
影响因子：
2.2
通讯作者：
Chaparro SV
中科院分区：
文献类型：
--
作者：
Hare JM;Chaparro SV
心脏再生和干细胞治疗领域最近取得了重大进展。了解细胞疗法的新技术进步最终将使我们能够实现基于细胞的心脏修复的目标。我们讨论最新的细胞疗法（包括骨骼肌母细胞、骨髓源性细胞、干细胞）、最近的人体临床试验和不同的递送技术。心脏再生背后的机制和临床复杂性的不断揭示将推动再生医学领域的发展。通过并行进行基础科学研究和纳入机械评估的临床试验，正在取得实质性进展。
Significant recent developments have occurred in the field of cardiac regeneration and stem-cell therapy. Understanding the new technological advances in cell therapy will ultimate allow us to achieve a goal of cell-based cardiac repair. We discuss the latest cell-based therapies (including skeletal myoblasts, bone-marrow-derived cells, stem cells), the recent clinical trials in humans and different delivery techniques. Ongoing unraveling of the mechanistic and clinical complexities underlying cardiac regeneration will advance the field of regenerative medicine. Substantial progress is being made by the parallel conduct of basic science studies and clinical trials that are incorporating mechanistic evaluations.