Anemia in children with down syndrome.
Anemia in children with down syndrome.
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DOI：
10.1155/2011/813541
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发表时间：
2011
影响因子：
2.1
通讯作者：
Stepensky P
中科院分区：
文献类型：
--
作者：
Tenenbaum A;Malkiel S;Wexler ID;Levy-Khademi F;Revel-Vilk S;Stepensky P
背景缺铁性贫血影响认知发育。本研究的目的是确定唐氏综合征儿童贫血和缺铁的患病率，并确定贫血的危险因素。方法.我们对参加多学科唐氏综合征医疗中心的儿童进行了一项前瞻性横断面研究。149名0-20岁的唐氏综合征儿童参加了这项研究。获得的信息包括病史、体格和发育检查、营养评估和血液检查结果。结果在研究的患者中，发现8.1%患有贫血。在38名接受铁研究的儿童中，50.0%的儿童患有铁缺乏症。在多变量分析中，阿拉伯民族和低体重与贫血显著相关。性别、身高、饮食失调和先天性心脏病不是贫血的危险因素。结论.患有唐氏综合症的儿童与一般人群一样，有贫血和缺铁的风险。应监测唐氏综合征儿童的贫血和缺铁情况，以便及时采取干预措施。
Background. Iron deficiency anemia impacts on cognitive development. The objective of this study was to determine the prevalence of anemia and iron deficiency in children with Down syndrome and identify risk factors for anemia. Methods. We conducted a prolective cross-sectional study of children attending a multidisciplinary Down syndrome medical center. One hundred and forty nine children with Down syndrome aged 0–20 years were enrolled in the study. Information obtained included a medical history, physical and developmental examination, nutritional assessment, and the results of blood tests. Results. Of the patients studied, 8.1% were found to have anemia. Among the 38 children who had iron studies, 50.0% had iron deficiency. In a multivariate analysis, Arab ethnicity and low weight for age were significantly associated with anemia. Gender, height, the presence of an eating disorder, and congenital heart disease were not risk factors for anemia. Conclusions. Children with Down syndrome are at risk for anemia and iron deficiency similar to the general population. Children with Down syndrome should be monitored for anemia and iron deficiency so that prompt intervention can be initiated.