Smoke visualization for the invasion of pollutants during door-opening process in pharmaceutical cleanrooms: Effects of initial pressure differential and airlock barriers
Smoke visualization for the invasion of pollutants during door-opening process in pharmaceutical cleanrooms: Effects of initial pressure differential and airlock barriers
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DOI：
10.1016/j.enbuild.2022.112711
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发表时间：
2022-12
影响因子：
6.7
通讯作者：
Xiaoliang Shao;Yemin Liu;Yunfeng Hao;Xueying Wen;Chunwang Li;Xiaojun Ma;Huan Wang;Xianting Li
中科院分区：
文献类型：
--
作者：
Xiaoliang Shao;Yemin Liu;Yunfeng Hao;Xueying Wen;Chunwang Li;Xiaojun Ma;Huan Wang;Xianting Li
制药洁净室在开门时如何防止污染侵入的研究很少。本研究建立了洁净制药实验室，并进行了烟气可视化实验。研究了房间之间的初始压差、气闸屏障和气闸门的时间延迟对4.5 s正常门周期和人员进入的干扰遏制的瞬态影响。初始压差设定为5 - 25 Pa，气闸门的延迟时间设定为6 - 36 s。结果表明，洁净室的门操作和人员进入导致烟气侵入洁净室。压差的增加改善了对烟雾迁移的遏制。烟雾侵入量较低，在20和25 Pa的压差下开门后18 s，烟雾几乎不可见。即使每个气闸门上的压差小于5 Pa，气闸也表现出有效的缓冲效果。增大延时有利于消除污染气体在气锁舱内的迁移。当气闸门上的初始压差为5 Pa时，16 s的延迟时间显著降低了污染。这些发现可以为制药洁净室和其他受控空间的短期干扰的遏制提供指导。
Little research has been conducted on containing pollution invasion when the doors of pharmaceutical cleanrooms are opened. In this study, a clean pharmaceutical laboratory was built, and smoke visualization experiments were conducted. The transient effects of the initial pressure differential between rooms, airlock barrier, and time delay of airlock doors on the containment of disturbance by a normal door cycle of 4.5 s and by personnel entry were investigated. The initial pressure differentials were set from 5 to 25 Pa, and the delay time of the airlock doors was set from 6 to 36 s. The results indicated that the door operation and personnel entry caused smoke to invade the cleanroom. An increase in the pressure differential improved the containment of smoke migration. The amount of smoke invasion was lower, and the smoke was almost invisible by 18 s after the door opening at differential pressures of 20 and 25 Pa. An airlock exhibited an effective buffer effect even if the pressure differential across each airlock door was less than 5 Pa. Increasing the time delay was beneficial for eliminating migrated polluted air in the airlock. A delay time of 16 s significantly reduced the pollution for an initial pressure differential of 5 Pa across the airlock door. These findings can provide guidance for the containment of short-term disturbances in pharmaceutical cleanrooms and other controlled spaces.