Meibomian gland dysfunction in patients with Sjogren syndrome
Meibomian gland dysfunction in patients with Sjogren syndrome
复制标题
Sjogren 综合征患者的睑板腺功能障碍
DOI：
10.1016/s0161-6420(98)98033-2
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发表时间：
1998-08-01
期刊：
影响因子：
13.7
通讯作者：
Tsubota, K
中科院分区：
文献类型：
--
作者：
Shimazaki, J;Goto, E;Tsubota, K
目的：干燥综合征 (SS) 患者的眼表变化往往比无 SS 的干眼患者更严重，本研究旨在探讨睑板腺功能障碍是否可能参与 SS 相关眼表异常。设计：一项非随机、前瞻性临床研究。参与者：对 27 名连续 SS 患者（SS 组）的 27 只眼睛进行研究。以年龄和性别相匹配的水性泪液缺乏的非SS患者（非SS组）29只眼为对照对象，干预措施：检查眼表、泪液功能和睑板腺的变化，主要指标：测量泪液蒸发率、睑板腺表达和睑板腺造影。结果：SS组的荧光素和孟加拉玫瑰染色评分显着高于非SS组(P=0.0001)，与非SS组相比，SS组泪液蒸发显着增加，SS组与非SS组泪液产生率无显着差异。睑板腺造影显示，SS 组 19 只眼中有 11 只（57.9%）在超过一半的睑板出现腺体脱落（即睑板腺的组织学破坏），其发生率显着高于非 SS 组（27 只眼中有 5 只 [18,5%]；P = 0.005）。泪液蒸发的增加往往与 SS 患者眼表的变化有关，SS 患者眼表的严重变化可能部分归因于睑板腺功能障碍。
Objective: Changes in the ocular surface of patients with Sjogren syndrome (SS) often are more severe than those in patients with dry eye without SS, This study was conducted to investigate the possible involvement of meibomian gland dysfunction in SS-related ocular surface abnormalities.Design: A nonrandomized, prospective, clinical study.Participants: Twenty-seven eyes of 27 consecutive patients with SS (SS group) were studied. Twenty-nine eyes of age- and gender-matched non-SS patients with aqueous tear deficiency (non-SS group) were examined as control subjects,Intervention: Changes in the ocular surface, tear function, and meibomian gland were examined,Main Outcome Measures: Tear evaporation rate, meibomian gland expression, and meibography were measured.Results: Fluorescein and rose bengal staining scores were significantly higher in the SS group than in the non-SS group (P = 0.0001), Evaporation of tears was increased significantly in the SS group compared with the non-SS group, There were no significant differences in the rate of tear production between the SS and non-SS groups. Meibography showed that 11 (57.9%) of 19 eyes in the SS group had gland dropout (i.e., histologic destruction of meibomian glands) in more than half of the tarsus, The incidence was significantly higher than that in the non-SS group (5 [18,5%] of 27 eyes; P = 0.005),Conclusions: The results of this study indicate that destruction of meibomian glands and an increase in tear evaporation often are associated with changes in the ocular surface in patients with SS, Severe ocular surface changes in patients with SS may be attributed, in part, to the meibomian gland dysfunction.