BRAIN-STEM AUDITORY EVOKED-POTENTIALS IN THE RAT - EFFECTS OF GENDER, STIMULUS CHARACTERISTICS AND ETHANOL SEDATION
BRAIN-STEM AUDITORY EVOKED-POTENTIALS IN THE RAT - EFFECTS OF GENDER, STIMULUS CHARACTERISTICS AND ETHANOL SEDATION
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DOI：
10.1016/0168-5597(84)90050-9
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
HOLLOWAY, JA
中科院分区：
文献类型：
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作者：
CHURCH, MW;WILLIAMS, HL;HOLLOWAY, JA
大鼠 BAEP（脑听觉诱发电位）随性别、乙醇镇静以及刺激强度和重复率的变化而显着变化。随着刺激强度的增加，所有 BAEP 波潜伏期均减少，振幅增加。与普遍观点相反，I-V 峰间潜伏期随着刺激强度的变化而发生显着变化。就重复率而言，随着重复率的增加，所有 BAEP 波的潜伏期均增加，振幅减小。与雌性相比，雄性大鼠在多种 BAEP 成分和峰间潜伏期方面具有显着更长的潜伏期，并且在广泛的刺激强度范围内具有较小的波 II 振幅。与女性相比，男性在慢刺激重复率（8次点击/秒）下的BAEP波IV潜伏期和I-IV峰间潜伏期也更长，但在快速重复率（120次点击/秒）下波IV和I-IV潜伏期更短。这些性别依赖性差异表明雄性和雌性大鼠 BAEP 数据不应不加区别地合并。乙醇镇静对 I-IV 峰间潜伏期具有统计学上的显着影响，该影响被认为在很大程度上与核心温度变化无关。这一发现表明，虽然用于固定动物的镇静剂和麻醉剂可能对 BAEP 潜伏期具有明显的较小的与温度无关的影响，但这些影响可能具有统计学意义。
Rat BAEP [brain auditory evoked potential] varied significantly as a function of gender and ethanol sedation as well as stimulus intensity and repetition rate. All BAEP wave latencies decreased and amplitudes increased with increasing stimulus intensity. Contrary to the prevailing view, I-V interpeak latency changed significantly as a function of stimulus intensity. In terms of repetition rate, all BAEP wave latencies increased and amplitudes decreased with increasing repetition rate. Male rats, compared to females, had significantly longer latencies for several BAEP components and interpeak latencies as well as smaller wave II amplitudes across a broad range of stimulus intensities. Males, compared to females, also had longer BAEP wave IV latencies and I-IV interpeak latencies at a slow stimulus repetition rate (8 clicks/s) but shorter wave IV and I-IV latencies at a fast repetition rate (120 clicks/s). These gender-dependent differences indicate that male and female rat BAEP data should not be combined indiscriminantly. Ethanol sedation had a statistically significant effect on the I-IV interpeak latency that was judged to be largely independent of core temperature changes. This finding suggests that while sedatives and anesthetics used to immobilize animals may have apparently minor temperature-independent effects on BAEP latencies, these effects can be statistically significant.