Push-pull control of motor output.
Push-pull control of motor output.
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DOI：
10.1523/jneurosci.4709-11.2012
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发表时间：
2012-03-28
期刊：
影响因子：
--
通讯作者：
Heckman CJ
中科院分区：
文献类型：
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作者：
Johnson MD;Hyngstrom AS;Manuel M;Heckman CJ
抑制通常会降低神经元的输入-输出兴奋性。然而，如果抑制与兴奋以推拉方式耦合，其中抑制随着兴奋的增加而减少，则神经元的兴奋性可以增加。虽然推拉组织的存在已经在单个细胞中得到证实，但其对神经处理的功能影响取决于其对系统水平的影响。我们研究了猫脊髓运动输出阶段的推挽，这是一个依赖性控制抑制和兴奋成分的系统。推拉组织明显存在于踝伸肌运动神经元，产生增加的峰到峰调制的突触电流。系统层面的影响同样强烈。抑制成分的独立控制表明，抑制背景越强，产生的峰值力越大。这说明了推拉组织的核心矛盾：通过增加背景抑制来提供更大的去抑制，可以实现更大的力量输出。
Inhibition usually decreases input-output excitability of neurons. If, however, inhibition is coupled to excitation in a push-pull fashion, where inhibition decreases as excitation increases, neuron excitability can be increased. Although the presence of push-pull organization has been demonstrated in single cells, its functional impact on neural processing depends on its effect on the system level. We studied push-pull in the motor output stage of the feline spinal cord, a system which hallows in dependent control of inhibitory and excitatory components. Push-pull organization was clearly present in ankle extensor motoneurons, producing increased peak to peak modulation of synaptic currents. The effect at the system level was equally strong. Independent control of the inhibitory component showed that the stronger the background of inhibition, the greater the peak force production. This illustrates the paradox at the heart of push-pull organization: increased force output can be achieved by increasing background inhibition to provide greater disinhibition.