Mineral intake and lung cancer risk in the NIH-American Association of Retired Persons Diet and Health study.
Mineral intake and lung cancer risk in the NIH-American Association of Retired Persons Diet and Health study.
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DOI：
10.1158/1055-9965.epi-10-0067
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发表时间：
2010-08
期刊：
影响因子：
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通讯作者：
Schatzkin A
中科院分区：
文献类型：
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作者：
Mahabir S;Forman MR;Dong YQ;Park Y;Hollenbeck A;Schatzkin A
使用病例对照研究的数据，我们之前报告了低镁(镁)、铁(铁)、锌(锌)、铜(铜)的饮食摄入，而不是硒(Se)和钙(Ca)的摄入量与肺癌风险的增加有关。由于病例对照研究中的饮食回忆偏差，我们的目标是评估这些发现在前瞻性队列研究中是否成立。我们分析了来自NIH-AARP饮食和健康研究的数据，这些研究对象是482,875名受试者(288,257名男性和194,618名女性)，他们在1995年至2003年注册时没有患癌症，并完成了食物频率问卷(FFQ)。计算COX比例风险模型以估计经潜在混杂因素调整后的相对危险度(RR)。在平均7年的随访中，发现了7052例肺癌病例。对于所有受试者，我们没有观察到总(饮食+补充剂)钙、镁、铁、铜、硒和锌的摄入量与肺癌风险之间的显著关联。总钙摄入量对当前吸烟者和腺癌受试者有保护作用(P-趋势和0.05)。在男性和当前吸烟者中，镁的总摄入量增加了风险(P-趋势和0.05)。在女性中，总的铁摄入量与风险呈负相关(P-趋势<；0.01)。对于膳食矿物质，镁增加了所有受试者、男性和当前吸烟者的风险(P-趋势和0.05)。增加膳食钙摄入量可降低女性患病风险(P-趋势=0.05)。膳食铁降低了所有受试者和女性的患病风险(P-Trend<；0.05)。从补充剂中摄取矿物质并不影响患肺癌的风险。饮食中的矿物质摄入可能会影响患肺癌的风险，但这种关联因矿物质类型和人群亚群而异。
Using data from a case-control study, we previously reported that low dietary intakes of magnesium (Mg), iron (Fe), zinc (Zn), copper (Cu), but not selenium (Se) and calcium (Ca) were associated with increased lung cancer risk. Due to dietary recall bias in case-control studies our objective was to assess whether these findings hold in a prospective cohort study. We analyzed data from the NIH-AARP Diet and Health study of 482,875 subjects (288,257 men and 194,618 women) who were cancer-free and completed a food frequency questionnaire (FFQ) at enrollment between 1995 and 2003. Cox proportional hazards models were computed to estimate the relative risk (RR) adjusted for potential confounders. During a mean follow-up of 7 years, 7,052 lung cancer cases were identified. For all subjects, we observed no significant associations between total (diet + supplement) Ca, Mg, Fe, Cu, Se, and Zn intakes and lung cancer risk. Total Ca intake was protective (P-trend<0.05) for current smokers and subjects with adenocarcinomas. Total Mg intake increased risk (P-trend<0.05) in men and current smokers. Total Fe intake was inversely associated with risk in women (P-trend<0.01). For dietary minerals, Mg increased risk (P-trend<0.05) in all subjects, among men and current smokers. Increased dietary Ca intake reduced risk in women (P-trend=0.05). Dietary Fe decreased risk in all subjects and among women (P-trend<0.05). Mineral intake from supplements did not affect lung cancer risk. Dietary mineral consumption may influence lung cancer risk, but the associations differ by type of mineral and population subgroups.