A Low-Cost, Accurate, and High-Precision Fluid Dispensing System for Microscale Application.
A Low-Cost, Accurate, and High-Precision Fluid Dispensing System for Microscale Application.
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DOI：
10.1177/2211068216676082
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发表时间：
2017-04
期刊：
影响因子：
2.7
通讯作者：
Nguyen C
中科院分区：
文献类型：
--
作者：
Das C;Wang G;Nguyen C
我们在这里提出，低成本，准确和精确的流体点胶系统的发展。它可以与蠕动泵或任何其他泵一起使用，以改善流量特性。该点胶系统的范围为1-100 μL，整个范围内的准确度约为99.5%，标准偏差约为150 nL。所开发的系统不依赖于驱动泵的准确度或精度;因此，任何正排量泵都可以用于获得类似的准确度和精度，这提供了降低系统成本的机会。该分配系统不需要定期校准，并且还可以小型化以用于微流体应用。虽然主要是针对水性液体设计的，但它可以扩展到不同的非导电液体以及修改。该装置还用于近实时测量微透析液中的乳酸盐。单个组分可以容易地制成一次性的或消毒的，以用于生物医学应用。
We present here, the development of a low cost, accurate and precise fluid dispensing system. It can be used with peristaltic or any other pump to improve the flow characteristics. The dispensing system has a range of 1–100 μL with accuracy of ~ 99.5% and standard deviation at ~150 nL over the entire range. The system developed does not depend on the accuracy or precision of the driving pump; thereby any positive displacement pump can be used to get similar accuracy and precision, which gives an opportunity to reduce the cost of the system. The dispensing system does not require periodic calibration and can also be miniaturized for microfluidic application. Though primarily designed for aqueous liquid, it can be extended for different non-conductive liquids as well with modifications. The unit is further used for near real-time measurement of Lactate from microdialysate. The individual components can easily be made disposable or sterilized for use in biomedical application.