Common and stimulus-type-specific brain representations of negative affect
Common and stimulus-type-specific brain representations of negative affect
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DOI：
10.1038/s41593-022-01082-w
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发表时间：
2022-05-30
影响因子：
25
通讯作者：
Wager, Tor D.
中科院分区：
文献类型：
--
作者：
Ceko, Marta;Kragel, Philip A.;Wager, Tor D.
大脑包含厌恶事件的广义表征和特定于刺激类型的表征，但缺乏这些表征如何整合以及如何与主观体验相关的模型。我们将功能性磁共振成像与预测模型相结合，以识别机械痛、热痛、厌恶声音和四个强度级别的厌恶图像的广义（常见）和刺激类型特异性负面影响的表征。这使我们能够研究广义表征和特定刺激表征如何共同促成厌恶体验。刺激类型特异性的负面情绪主要编码在早期感觉通路中，而广义负面情绪则编码在一组分布的中线、前脑、岛叶和体感区域中。所有模型都专门预测负面情绪，而不是一般的显着性或唤醒性，并准确预测独立样本中的负面情绪，证明了稳健性和普遍性。通用模型和特定刺激类型模型对于预测主观体验同样重要。总之，这些发现提供了关于负面情绪如何在大脑中构建的综合解释，并为未来的研究提供了预测性神经标志物。Ceko 等人使用多种类型的负面情绪刺激、功能磁共振成像和预测模型。研究表明，大脑整合了厌恶事件的广义和特定刺激类型的表征，以共同预测主观体验。
The brain contains both generalized and stimulus-type-specific representations of aversive events, but models of how these are integrated and related to subjective experience are lacking. We combined functional magnetic resonance imaging with predictive modeling to identify representations of generalized (common) and stimulus-type-specific negative affect across mechanical pain, thermal pain, aversive sounds and aversive images of four intensity levels each. This allowed us to examine how generalized and stimulus-specific representations jointly contribute to aversive experience. Stimulus-type-specific negative affect was largely encoded in early sensory pathways, whereas generalized negative affect was encoded in a distributed set of midline, forebrain, insular and somatosensory regions. All models specifically predicted negative affect rather than general salience or arousal and accurately predicted negative affect in independent samples, demonstrating robustness and generalizability. Common and stimulus-type-specific models were jointly important for predicting subjective experience. Together, these findings offer an integrated account of how negative affect is constructed in the brain and provide predictive neuromarkers for future studies.Using multiple types of negative affect stimuli, functional magnetic resonance imaging and predictive modeling, Ceko et al. show that the brain integrates generalized and stimulus-type-specific representations of aversive events to jointly predict subjective experience.