Enhancement of learning processes following an acute modafinil injection in mice
Enhancement of learning processes following an acute modafinil injection in mice
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DOI：
10.1016/j.pbb.2003.09.007
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发表时间：
2003-12-01
影响因子：
3.6
通讯作者：
Pierard, C
中科院分区：
文献类型：
--
作者：
Béracochéa, D;Celerier, A;Pierard, C
莫达非尼是一种促进觉醒的药物，对治疗嗜睡症有效;但其对学习过程的影响研究甚少。因此，本研究旨在确定急性莫达非尼注射对小鼠在T-迷宫中进行的系列逆转辨别任务的影响。使用根据预测试训练水平（训练1天或4天）而变化的独立小鼠组。每天在每次训练开始前给小鼠注射阿拉伯树胶溶液。在训练的第二天或第五天，在测试前注射单剂量的莫达非尼。与对照组相比，64 mg/kg莫达非尼显著改善了训练4天的受试者的表现，但32 mg/kg莫达非尼没有改善训练1天的受试者的表现。这种学习的改善是由于与对照组相比，莫达非尼治疗组受试者更快地出现了赢-留策略。因此，我们的数据表明，急性莫达非尼注射增强学习过程。(C)2003年爱思唯尔公司All rights reserved.
Modafinil is a wakeness-promoting drug, which is effective in the treatment of narcolepsy; its effects on learning processes are however little studied. Thus, the present study was aimed at determining the effects of an acute modafinil injection on a serial reversal discrimination task performed in a T-maze in mice. Independent groups of mice varying by the level of pretest training (either 1 or 4 days of training) were used. Mice were injected each day with a gum arabic solution before each session began. On the second or the fifth day of training, a single dose of modafinil was injected before testing. Modafinil at 64 mg/kg but not at 32 mg/kg dramatically improved performance as compared to controls in subjects being trained 4 days, but not in subjects being trained 1 day. This improvement of learning was due to the more rapid emergence of a win-stay strategy in modafinil-treated subjects as compare to controls. Thus, our data show that an acute modafinil injection enhances learning processes. (C) 2003 Elsevier Inc. All rights reserved.