The association between trauma exposure, polygenic risk and individual depression symptoms.
The association between trauma exposure, polygenic risk and individual depression symptoms.
复制标题
创伤暴露、多基因风险和个体抑郁症状之间的关联。
DOI：
10.1016/j.psychres.2023.115101
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发表时间：
2023
影响因子：
11.3
通讯作者：
Derks,EskeM
中科院分区：
文献类型：
--
作者：
Thorp,JacksonG;Gerring,ZacharyF;Colodro-Conde,Lucía;Byrne,EndaM;Medland,SarahE;Middeldorp,ChristelM;Derks,EskeM
背景创伤经历与重度抑郁症（MDD）的风险增加有关。本研究旨在确定的程度，创伤暴露，抑郁症多基因风险评分（PRS），以及它们的相互作用与MDD和个人抑郁症symptoms.MethodsData从102,182个人从大规模的英国生物银行人口队列进行了分析。进行了一系列回归分析，以估计创伤、抑郁PRS与1）当前抑郁症、2）终生MDD病例对照状态、3）9个当前抑郁症状个体和4）重度抑郁发作期间经历的13个个体症状之间的关联。添加剂和乘法PRS的创伤相互作用也assessed.ResultsTrauma和抑郁症PRS显着相关，目前的抑郁症和终身MDD。一个积极的，添加剂的相互作用效果，观察抑郁症，但乘法的相互作用并不显着。创伤暴露和抑郁PRS与抑郁症状的特定模式相关;创伤与低自尊、自杀意念和非典型（但不典型）植物神经症状相关。添加剂的相互作用的影响，观察到6个目前的9个抑郁症symptoms.ConclusionsTrauma暴露和抑郁症的遗传易感性可能会导致特定的抑郁症，这可能有助于极端的临床异质性观察到的个人与抑郁症。
BackgroundTraumatic experiences are associated with increased risk for major depressive disorder (MDD). This study sought to determine the extent that trauma exposure, depression polygenic risk scores (PRS), and their interaction are associated with MDD and individual depression symptoms.MethodsData from 102,182 individuals from the large-scale UK Biobank population cohort was analysed. A series of regression analyses were conducted to estimate the association between trauma, depression PRS and 1) current depression, 2) lifetime MDD case-control status, 3) nine individual current depressive symptoms, and 4) thirteen individual symptoms experienced during a major depressive episode. Additive and multiplicative PRS-by-trauma interactions were also assessed.ResultsTrauma and depression PRS were significantly associated with both current depression and lifetime MDD. A positive, additive interaction effect was observed on depression, but multiplicative interactions were not significant. Trauma exposure and depression PRS were associated with specific patterns of depression symptoms; Trauma was associated with low self-esteem, suicidal ideation, and atypical (but not typical) neurovegetative symptoms. Additive interaction effects were observed on six out of nine current depressive symptoms.ConclusionsTrauma exposure and genetic predisposition to depression may lead to particular symptomatology, which may contribute to the extreme clinical heterogeneity observed in individuals with major depression.