Design and Manufacture of Combinatorial Calcium Phosphate Bone Scaffolds
Design and Manufacture of Combinatorial Calcium Phosphate Bone Scaffolds
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DOI：
10.1115/1.4005173
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发表时间：
2011-10-01
影响因子：
1.7
通讯作者：
Johnson, Amy J. Wagoner
中科院分区：
文献类型：
--
作者：
Hoelzle, David J.;Svientek, Shelby R.;Johnson, Amy J. Wagoner
众所周知，孔隙设计是人工骨组织支架中再生骨的数量和分布的重要决定因素。一个必要的特征是支架必须包含100-1000 μ m数量级的孔互连（称为大孔隙）。在此范围内，没有确定的最佳互连尺寸。最近的结果表明，渗透支架构建材料的2-20 μ m数量级的孔互连（称为微孔）驱动骨以更快的速率生长到大孔空间中，并且还为骨生长提供了新的空间，在整个互连的微孔网络中增殖。微观结构特征对骨生长的影响尚未完全了解。这项工作提出了新的组合测试支架，测试多个微孔和大孔设计在一个单一的支架支架的制造和表征。这样的支架可以有效地评估多个机械设计，其优点是使设计共同定位在单个缺陷部位内，因此不易受实验变化的影响。本文提供了制造平台，制造控制方法，并展示了三个有代表性的支架的制造能力。[DOI 10.1115/1.4005173]
It is well known that pore design is an important determinant of both the quantity and distribution of regenerated bone in artificial bone tissue scaffolds. A requisite feature is that scaffolds must contain pore interconnections on the order of 100-1000 mu m (termed macroporosity). Within this range, there is not a definitive optimal interconnection size. Recent results suggest that pore interconnections permeating the scaffold build material on the order of 2-20 mu m (termed microporosity) drive bone growth into the macropore space at a faster rate and also provide a new space for bone growth, proliferating throughout the interconnected microporous network. The effects of microstructural features on bone growth has yet to be fully understood. This work presents the manufacture and characterization of novel combinatorial test scaffolds, scaffolds that test multiple microporosity and macroporosity designs within a single scaffold. Scaffolds such as this can efficiently evaluate multiple mechanical designs, with the advantage of having the designs colocated within a single defect site and therefore less susceptible to experimental variation. This paper provides the manufacturing platform, manufacturing control method, and demonstrates the manufacturing capabilities with three representative scaffolds. [DOI: 10.1115/1.4005173]