Opposing roles for dopamine D1- and D2-like receptors in discrete cue-induced reinstatement of food seeking
Opposing roles for dopamine D1- and D2-like receptors in discrete cue-induced reinstatement of food seeking
复制标题
DOI：
10.1016/j.bbr.2011.03.064
复制
发表时间：
2011-09-23
影响因子：
2.7
通讯作者：
Beyer, Denise N.
中科院分区：
文献类型：
--
作者：
Ball, Kevin T.;Combs, Tarra A.;Beyer, Denise N.
我们使用大鼠恢复模型来测试多巴胺D-1和D-2样受体在离散线索诱导的食物寻求恢复中的参与。在不改变食物自我给药期间反应的剂量下，D-1样拮抗剂SCH-23390阻断了食物寻求的恢复，而D-2样拮抗剂依替氯必利显著增加了恢复反应。因此，这些结果建立了相反的作用，D-1和D-2样受体在离散线索诱导复发的食物寻求。(C)2011 Elsevier B. V.保留所有权利。
We used a rat reinstatement model to test the involvement of dopamine D-1- and D-2-like receptors in discrete cue-induced reinstatement of food seeking. At a dose that did not alter responding during food self-administration, the D-1-like antagonist SCH-23390 blocked reinstatement of food seeking, while the D-2-like antagonist eticlopride significantly increased reinstatement responding. Thus, these results establish opposing roles for D-1- and D-2-like receptors in discrete cue-induced relapse to food seeking. (C) 2011 Elsevier B.V. All rights reserved.