Structural Analysis of Red Blood Cell Aggregates Under Shear Flow
Structural Analysis of Red Blood Cell Aggregates Under Shear Flow
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DOI：
10.1007/s10439-009-9871-2
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发表时间：
2010-03-01
影响因子：
3.8
通讯作者：
Marshall, J. S.
中科院分区：
文献类型：
--
作者：
Chesnutt, J. K. W.;Marshall, J. S.
发展了一套红细胞聚集体的测量方法，并将其应用于研究平面剪切和槽道流动下的红细胞聚集体结构。其中一些测量是基于在给定时间相互接触的一组红细胞的平均值。其他测量方法是：首先将椭圆与集合体的平面投影进行拟合，然后检查拟合椭圆的面积和纵横比以及组成红细胞相对于拟合椭圆轴的方向。聚集体结构测量是使用一个新的血细胞传输、碰撞和黏附的中尺度计算模型来说明的。考察了该模型对胶粘剂表面能密度和骨料结构剪切率变化的敏感性。结果表明，对于平面剪切和槽道流动中的血液流动，中尺度模型的预测结果与实验和理论数据吻合较好。新的结构措施被用来检查对集合体形成的二维和三维计算的预测之间的差异，表明二维计算保留了三维计算的一些重要方面。
A set of measures of red blood cell (RBC) aggregates are developed and applied to examine the aggregate structure under plane shear and channel flows. Some of these measures are based on averages over the set of red blood cells which are in contact with each other at a given time. Other measures are developed by first fitting an ellipse to the planar projection of the aggregate, and then examining the area and aspect ratio of the fit ellipse as well as the orientations of constituent RBCs with respect to the fit ellipse axes. The aggregate structural measures are illustrated using a new mesoscale computational model for blood cell transport, collision and adhesion. The sensitivity of this model to change in adhesive surface energy density and shear rate on the aggregate structure is examined. It is found that the mesoscale model predictions exhibit reasonable agreement with experimental and theoretical data for blood flow in plane shear and channel flows. The new structural measures are used to examine the differences between predictions of two- and three-dimensional computations of the aggregate formation, showing that two-dimensional computations retain some of the important aspects of three-dimensional computations.