Animal models for the study of Helicobacter-induced gastric carcinoma
Animal models for the study of Helicobacter-induced gastric carcinoma
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DOI：
10.1007/s10156-004-0353-z
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发表时间：
2004-12-01
影响因子：
2.2
通讯作者：
Fujioka, Toshio
中科院分区：
文献类型：
--
作者：
Kodama, Masaaki;Murakami, Kazunari;Fujioka, Toshio
幽门螺杆菌被认为与胃癌密切相关。许多流行病学研究表明，慢性H。幽门螺杆菌感染和随后的人类胃癌的发展。为了更清楚地阐明这一联系，有必要在实验研究中使用这种细菌在合适的实验动物中发展胃癌。持久H.在日本猴模型中观察到幽门螺杆菌感染，最近在蒙古沙鼠模型中也实现了。在这些模型中，胃粘膜的连续组织病理学变化与人类非常相似。日本猴模型在长期观察中显示胃粘膜萎缩性改变和p53点突变的进展。长爪沙鼠模型表明H. pylori感染与已知的致癌物如N-甲基-N-亚硝基脲（MNU）和N-甲基-N-硝基-N ′-亚硝基胍（MNNG）联合可增强胃癌的发生。幽门螺杆菌感染本身可导致胃癌的发展。这些重要结果为进一步阐明H.幽门螺杆菌感染，并协助规划根除治疗，以预防胃癌。
Helicobacter pylori is considered to have a close association with gastric cancer. Many epidemiological studies have shown a strong association between chronic H. pylori infection and subsequent development of gastric carcinoma in humans. To clarify this link more clearly, it is necessary to use this bacterium in experimental studies to develop gastric carcinoma in suitable experimental animals. Persistent H. pylori infection was seen in the Japanese monkey model, and has recently been achieved in the Mongolian gerbil model. In these models, the sequential histopathological changes in the gastric mucosa are very similar to those in humans. The Japanese monkey model showed advances in atrophic change and p53 point mutations in the gastric mucosa during long-term observation. The Mongolian gerbil model demonstrated that H. pylori infection enhances gastric carcinogenesis in combination with known carcinogens such as N-methyl-N-nitrosourea (MNU) and N-methyl-N-nitro-N'-nitrosoguanidine (MNNG), and also showed that H. pylori infection alone can result in the development of gastric carcinoma. These important results provide a starting point for further studies to clarify the mechanism of gastric carcinogenesis as a result of H. pylori infection and assist in the planning of eradication therapy to prevent gastric carcinoma.