Expression of CD147 Mediates Tumor Cells Invasion and Multidrug Resistance in Hepatocellular Carcinoma
Expression of CD147 Mediates Tumor Cells Invasion and Multidrug Resistance in Hepatocellular Carcinoma
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CD147表达介导肝细胞癌肿瘤细胞侵袭和多药耐药
DOI：
10.1080/07357900802072723
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Zhang, Jianing
中科院分区：
文献类型：
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作者：
Jia, Li;Xu, Henggui;Zhang, Jianing
多药耐药（MDR）肿瘤细胞过度表达P-糖蛋白表现出侵袭行为的变化。为了研究其机制，我们分析了CD 147的表达。结果显示，与HepG 2细胞相比，HepG 2/Adr细胞中CD 147表达增加。MDR细胞产生更多的MMP 11和MDR 1，促进HepG 2/Adr细胞的侵袭，增加对化疗药物的耐药性。另一方面，通过RNAi沉默HepG 2/Adr细胞中的CD 147导致相反的效果。用MAPK/Erk抑制剂U-0126处理肿瘤细胞也下调MMP 11和MDR 1表达。因此，CD 147可能在功能上介导肿瘤细胞的侵袭和MDR。
Multidrug resistant (MDR) tumor cells over-expressing P-glycoprotein exhibit variation in invasive behavior. To investigate the mechanisms, we analyzed the expression of CD147. The results showed that CD147 expression was increased in HepG2/Adr cells, as compared to HepG2 cells. The MDR cells produced more MMP11 and MDR1, which promoted HepG2/Adr cells invasion and increased resistance to chemotherapeutic drugs. On the other hand, CD147 silencing in HepG2/Adr cells by RNAi led to the opposite effect. Treatment of tumor cells with U-0126, an inhibitor of MAPK/Erk, also down-regulated MMP11 and MDR1 expression. Thus, CD147 may functionally mediate tumor cells invasion and MDR.