Cervical cytomegalovirus excretion in pregnant and nonpregnant women: suppression in early gestation.
Cervical cytomegalovirus excretion in pregnant and nonpregnant women: suppression in early gestation.
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孕妇和非孕妇的宫颈巨细胞病毒排泄：妊娠早期的抑制。
DOI：
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发表时间：
1975
影响因子：
6.4
通讯作者：
C. Alford
中科院分区：
文献类型：
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作者：
S. Stagno;D. Reynolds;A. Tsiantos;D. Fuccillo;R. Smith;M. Tiller;C. Alford
对 659 名具有相似人口特征的孕妇和 202 名非孕妇进行比较，结果显示，宫颈巨细胞病毒排泄率总体相同（9.5% vs. 9.4%），而且出人意料地高，特别是因为 89% 的孕妇在参加研究时拥有巨细胞病毒抗体。孕妇中巨细胞病毒的患病率在妊娠早期 (1.6%) 显着低于妊娠晚期 (11.3%)。因此，早期妊娠似乎对病毒排泄产生抑制作用，这种抑制作用随着妊娠的进展而减弱。在 viuria 方面，两组中观察到类似但不太显着的情况。年龄的增长似乎也抑制了宫颈和尿路感染的病毒学表达，而多产似乎仅在宫颈中产生了这种效应。在宫颈排泄物和尿液排泄物中，少数在整个怀孕期间都会传播病毒，而另一些则间歇性地传播病毒。然而，病毒脱落最常见于妊娠晚期，并经常持续到产后期。没有记录原发感染，并且在大多数情况下，随着病毒排泄的出现，抗体状态保持不变。因此，内源性病毒的重新激活似乎是我们人群中病毒脱落的最可能的解释。排泄者和非排泄者中淋病奈瑟菌的分离率相似，进一步反驳了另一种主要可能性，即性病再感染。
Comparison of 659 pregnant and 202 nonpregnant women with similar demographic characteristics showed overall rates of cervical cytomegalovirus excretion that were identical (9.5% vs. 9.4%) and were surprisingly high, especially since 89% of the pregnant group possessed antibody to cytomegalovirus when admitted to the study. Prevalence of cytomegalovirus among gravidas was significantly lower during the first (1.6%) than during the third (11.3%) trimester. Thus, early pregnancy appeared to exert a suppressive effect on viral excretion that waned with advancing gestation. A similar but less significant occurrence was observed in the two groups with respect to viuria. Increasing age also appeared to suppress the virologic expression of cervical and urinary tract infection, whereas multiparity seemingly produced such an effect only in the cervix. Among both cervical and urinary excreters, a few shed virus thoughout pregnancy, and others shed virus intermittently; however, viral shedding most commonly began in late gestation and frequently continued into the postpartum period. Primary infection was not documented, and antibody status remained unchanged with the advent of viral excretion in most cases. Thus, reactivation of endogenous virus seems the most likely explanation for viral shedding in our population. Similar rates of isolation of Neisseria gonorrhoeae in excreters and nonexcreters further argue against the other major possibility, venereal reinfection.