Demographic, clinical, and virologic characteristics of African-born persons with HIV/AIDS in a Minnesota hospital
Demographic, clinical, and virologic characteristics of African-born persons with HIV/AIDS in a Minnesota hospital
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DOI：
10.1089/apc.2006.0074
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发表时间：
2007-05-01
影响因子：
4.9
通讯作者：
Henry, Keith
中科院分区：
文献类型：
--
作者：
Akinsete, Omobosola O.;Sides, Tracy;Henry, Keith
明尼苏达州目前是美国第十大非洲人口和第二大东非人口的家园。在明尼苏达州，越来越多的非洲出生的人被诊断出患有艾滋病毒。我们对1994年1月至2005年6月间在我们艾滋病诊所就诊的所有非洲出生的患者进行了回顾性调查。我们确定了237例非洲出生的HIV阳性患者。他们占研究期间就诊患者的12%。在艾滋病诊所中，非洲出生的患者和非非洲出生的患者的年龄没有显著差异。与非非洲患者相比，非洲出生的患者更有可能是女性（p < 0.001）。根据CD4(+) T细胞计数每毫升少于200个细胞的定义，43%的非洲出生的艾滋病患者表现为艾滋病，而在临床中，抗逆转录病毒初始的非非洲艾滋病患者的这一比例为33% （p < 0.001）。大多数患者是通过异性性接触感染的，只有4%的患者通过常规检测得到诊断。鉴定出7种已知的HIV亚型和4种独特的重组形式。最常见的机会性感染是肺结核。感染艾滋病毒的非洲移民似乎：(1)与我们诊所的其他患者相比，在艾滋病毒疾病的晚期获得护理；(2)常感染非B亚型；(3)不定期进行艾滋病毒检测。卫生保健提供者和公共卫生官员需要提高对这一日益增长的趋势的认识，以便为美国的非洲移民量身定制教育计划和预防措施。
Minnesota is currently home to the tenth largest African population and the second largest East African population in the United States. HIV is increasingly being diagnosed in African-born persons in Minnesota. A retrospective survey was conducted on all African- born patients in our HIV clinic between January 1994 and June 2005. We identified 237 patients who were African- born and HIV- positive. They constituted 12% of patients attending the clinic within the study timeframe. There was no significant difference in the ages of the African-born and non-African patients in the HIV clinic. African- born patients were more likely to be women compared with non-African patients ( p < 0.001). Forty- three percent of the African-born patients presented with AIDS as defined by CD4(+) T cell counts less than 200 cells per milliliter compared to 33% of antiretroviral naive non-African HIV patients in the clinic ( p < 0.001). Most patients were infected through heterosexual contact and only 4% were diagnosed as a result of routine testing. Seven known HIV subtypes and four unique recombinant forms were identified. The most common opportunistic infection was pulmonary tuberculosis. African immigrants with HIV appear to: ( 1) access care at later stages of HIV disease than other patients in our clinic; ( 2) are often infected with non- B subtypes; ( 3) do not routinely get tested for HIV. Increased awareness to this growing trend is needed for health care providers and public health officials to tailor educational programs and prevention efforts for African immigrants in the United States.