Nationwide trends of hospitalizations for cystic fibrosis in the United States from 2003 to 2013
Nationwide trends of hospitalizations for cystic fibrosis in the United States from 2003 to 2013
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DOI：
10.5582/irdr.2017.01043
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发表时间：
2017-08-01
影响因子：
1.3
通讯作者：
Wang, Janice
中科院分区：
文献类型：
--
作者：
Agrawal, Abhinav;Agarwal, Abhishek;Wang, Janice
囊性纤维化（CF）是一种多系统常染色体隐性遗传病，在过去的十年中，在早期诊断和治疗方面取得了重大进展。重要的是提供关于这些变化的人口统计学的最新信息，因为它们也反映了生存率的显著改善。我们分析了2003年至2013年美国国家住院患者样本数据库（NIS）中所有以CF为主要出院诊断（ICD-9：277.0-277.09）的患者，以评估CF的住院率，并确定与其他流行病学结果沿着的费用和死亡率。计算研究期间出院人数、住院时间和相关住院费用差异的统计学显著性。2003年，美国有8，328例出院诊断为CF，2013年增加到12，590例（p < 0.001）。平均住院费用从2003年的60 051美元增加到2013年的94 664美元，增加了57.64%。住院总费用增加了138.31%，从500 105 727美元增至1 191 819 760美元。同期死亡率下降49.3%。从2003年到2013年，与CF相关的住院出院人数有所增加。这是由于CF患者的预期寿命增加，导致疾病患病率增加。与CF入院相关的平均和总成本显著增加。在过去的十年中，CF的诊断和治疗取得了许多进展，从而导致这种慢性疾病的流行病学和人口统计学发生了重大转变。与CF患者的护理相关的医院成本上升需要未来的研究分析医生治疗CF患者的诊断模式，算法和治疗实践。
Cystic fibrosis (CF) is a multisystem autosomal recessive genetic disorder with significant advances in early diagnosis and treatment in the last decade. It is important to provide updated information regarding these changing demographics as they also reflect a considerable improvement in survival. We analyzed the National Inpatient Sample Database (NIS) in the United States for all patients in which CF was the primary discharge diagnosis (ICD-9: 277.0-277.09) from 2003 to 2013 to evaluate the rate of hospitalizations and determine the cost and mortality associated with CF along with other epidemiological findings. The statistical significance of the difference in the number of hospital discharges, lengths of stays and associated hospital costs over the study period was calculated. In 2003, there were 8,328 hospital discharges with the principal discharge diagnosis of CF in the United States, which increased to 12,590 discharges in 2013 (p < 0.001). The mean hospital charges increased by 57.64% from US$ 60,051 in 2003 to US$ 94,664 in 2013. The aggregate cost of hospital visits increased by 138.31% from US$ 500,105,727 to US$ 1,191,819,760. In the same time, the mortality decreased by 49.3 %. The number of inpatient discharges related to CF has increased from 2003 to 2013. This is due to increased life expectancy of CF patients, resulting in increased disease prevalence. There has been a significant increase in the mean and aggregate cost associated with CF admissions. Over the last decade, many advances have been made in the diagnosis and treatment of CF, consequentially leading to a significant transformation in the epidemiology and demographics of this chronic disease. Rising hospital costs associated with the care of CF patients necessitates future studies analyzing the diagnostic modalities, algorithms and treatment practices of physician's treating CF patients.