EVIDENCE FOR A NOVEL GENE ASSOCIATED WITH LOW TUMOR METASTATIC POTENTIAL
EVIDENCE FOR A NOVEL GENE ASSOCIATED WITH LOW TUMOR METASTATIC POTENTIAL
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DOI：
10.1093/jnci/80.3.200
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发表时间：
1988-04-06
影响因子：
10.3
通讯作者：
SOBEL, ME
中科院分区：
文献类型：
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作者：
STEEG, PS;BEVILACQUA, G;SOBEL, ME
我们描述了一个基因，NM 23，这是与肿瘤转移过程。在两个实验系统中，NM 23 RNA水平在转移潜能相对较低的细胞和肿瘤中最高：（1）鼠K-1735黑色素瘤细胞系，其中鉴定了该基因，和（2）N-亚硝基-N-甲基脲诱导的大鼠乳腺癌。NM 23 RNA水平与细胞对宿主免疫反应的敏感性无关，因此可能与内在攻击性有关。与Genebank动物、细菌和病毒序列相比，预测的pNM 23 cDNA克隆编码的羧基末端蛋白质序列是新颖的。
We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cells lines, in which the gene was identified, and (2) N-nitroso-N-methylurea-induced rat mammary carcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsic aggressiveness. The predicted carboxy-terminal protein sequence encoded by the pNM23 cDNA clone is novel compared with Genebank animal,bacterial, and viral sequences.