The Emerging Role of Wnt/PCP Signaling in Organ Formation
The Emerging Role of Wnt/PCP Signaling in Organ Formation
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DOI：
10.1089/zeb.2008.0563
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发表时间：
2009-03-01
期刊：
影响因子：
2
通讯作者：
Topczewski, Jacek
中科院分区：
文献类型：
--
作者：
Dale, Rodney M.;Sisson, Barbara E.;Topczewski, Jacek
在过去的二十年里，斑马鱼一直是研究脊椎动物发育的极好模式生物。结合基因敲除和其他操作的突变分析揭示了Wnt信号传导在发育过程中的重要作用，独立于β-连环蛋白。特别是Wnt/平面细胞极性（PCP）信号在原肠胚形成运动和神经形成的调节中的功能，在这个特殊问题的其他评论中描述。在这里，我们开始强调一些新的和令人兴奋的研究，正在进行的斑马鱼，以阐明Wnt/PCP信号在特定器官的形成中发挥的作用，包括侧线，颅面发育和再生。我们还总结了新出现的Wnt/PCP途径与初级纤毛功能，在几个器官活动的重要细胞器的连接。
Over the last two decades zebrafish has been an excellent model organism to study vertebrate development. Mutant analysis combined with gene knockdown and other manipulations revealed an essential role of Wnt signaling, independent of beta-catenin, during development. Especially well characterized is the function of Wnt/planar cell polarity (PCP) signaling in the regulation of gastrulation movements and neurulation, described in other reviews within this special issue. Here, we set out to highlight some of the new and exciting research that is being carried out in zebrafish to elucidate the role that Wnt/PCP signaling plays in the formation of specific organs, including the lateral line, craniofacial development, and regeneration. We also summarized the emerging connection of the Wnt/PCP pathway with primary cilia function, an essential organelle in several organ activities.