Effect of high-salt diet or chronic captopril treatment on exercise capacity in normotensive rats
Effect of high-salt diet or chronic captopril treatment on exercise capacity in normotensive rats
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DOI：
10.1111/j.1440-1681.2004.03980.x
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发表时间：
2004-04-01
影响因子：
2.9
通讯作者：
Kohzuki, M
中科院分区：
文献类型：
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作者：
Minami, N;Mori, N;Kohzuki, M
1.我们研究了长期抑制肾素-血管紧张素系统是否会影响血压正常大鼠的运动能力。将大鼠置于正常大鼠饲料、含卡托普利（100 mg/kg/天）的正常大鼠饲料或高盐饮食（HS; 4%）中4周。干预结束后，在运动平板上以10、20和30 m/min的速度递增运动4 min，同时测定血乳酸.与对照组大鼠相比，在20 m/min的速度下运动后的血乳酸显着更高，并且在此期间大鼠能够以30 m/min的速度跑步的持续时间显着更短.我们的结论是，长期治疗与卡托普利或HS饮食可以减少运动能力，在不活跃的血压正常大鼠，可能通过慢性抑制肾素-血管紧张素系统。
1. We investigated whether chronic suppression of the renin-angiotensin system, which is known to be associated with reductions in microvascular density and vasodilator responsiveness of skeletal muscle, could affect exercise capacity in normotensive rats.2. Rats were placed on normal rat chow, normal rat chow with captopril (100 mg/kg per day) or a high-salt diet (HS; 4%) for 4 weeks. Following these interventions, rats with indwelling carotid artery catheters were submitted to stepwise increasing exercise on a motor treadmill at a speed of 10, 20 and 30 m/min for 4 min while blood lactate was measured.3. Blood lactate after exercise at a speed of 20 m/min was significantly higher and the duration during which rats were able to run at a speed of 30 m/min was significantly shorter in captopril-treated rats and rats fed an HS diet compared with control rats.4. We conclude that chronic treatment with captopril or HS diet could reduce the exercise capacity in inactive normotensive rats, probably through chronic inhibition of the renin-angiotensin system.