Effect of Gentamicin Ointment in Patients with Nagashima-type Palmoplantar Keratosis: A Double-blind Vehicle-controlled Study.
Effect of Gentamicin Ointment in Patients with Nagashima-type Palmoplantar Keratosis: A Double-blind Vehicle-controlled Study.
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DOI：
10.2340/00015555-3760
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发表时间：
2021-02-11
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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作者：
庆大霉素软膏在治疗长岛型掌足底角化病方面具有潜力。然而，缺乏可靠的研究数据。本研究的目的是进行一项前瞻性、随机、双盲、对侧、载体对照的临床试验。共有20名通过基因检测被诊断为长岛型掌跖角化病的受试者，他们携带无义突变，参加了为期30天的研究。身体一侧手足涂庆大霉素软膏，另一侧手足涂车辆软膏。每个受试者的手和脚的选择是随机分配的。采用盲法评估者，使用Dermatology life quality Index、视觉模拟量表评分和数码摄影对患者皮肤病变的严重程度和生活质量进行评估。庆大霉素软膏治疗后角化过度和恶臭症状明显改善。庆大霉素与对照剂对红斑的影响无差异。综上所述，庆大霉素软膏治疗无义突变引起的长岛型掌跖角化病表现出积极的反应和良好的耐受性。
Gentamicin ointment has potential in the treatment of Nagashima-type palmoplantar keratosis. However, there is a lack of reliable study data. The aim of this study was to perform a prospective, randomized, double-blinded, contralateral, vehicle-controlled clinical trial. A total of 20 subjects diagnosed with Nagashima-type palmoplantar keratosis by genetic test, who carried nonsense mutations, enrolled in the 30-day study. Gentamicin ointment was applied to the hand and foot on one side of the body, and vehicle ointment was applied to the hand and foot on the other side. The choice of hand and foot in each subject was randomly allocated. The severity of the patient’s skin lesions and quality of life were assessed by a blinded evaluator, using the Dermatology Life Quality Index, visual analogue scale scores and digital photography. Gentamicin ointment treatment resulted in a significant improvement in symptoms of hyperkeratosis and foul smell compared with vehicle. No difference was found in the effect on erythema between gentamicin and vehicle. In conclusion, gentamicin ointment demonstrated positive responses and good tolerance in treating Nagashima-type palmoplantar keratosis caused by nonsense mutations.
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