Enhanced manual and oral motor reaction time in young adult female fragile X premutation carriers.
Enhanced manual and oral motor reaction time in young adult female fragile X premutation carriers.
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DOI：
10.1017/s1355617711000634
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发表时间：
2011-07
影响因子：
2.6
通讯作者：
Simon, Tony J.
中科院分区：
文献类型：
--
作者：
Goodrich-Hunsaker, Naomi J.;Wong, Ling M.;McLennan, Yingratana;Tassone, Flora;Harvey, Danielle;Rivera, Susan M.;Simon, Tony J.
关键词：
先前的一项研究报告了女性脆性X前突变携带者（fXPC）以更快的反应时间形式增强简单视觉信息处理的初步结果。在这项研究中，我们评估了30名女性fXPC和20名神经型（NT）对照的手动和口腔运动反应时间。参与者完成了两个版本的反应时间任务;一个版本需要手动运动反应，另一个版本需要口头运动反应。结果显示，女性fXPC显示更快的反应时间手动和口腔运动反应相对于NT控制。包括CGG重复长度、FMR 1 mRNA水平和年龄在内的分子指标与两组的表现无关。考虑到先前报道的在同一组前突变携带者中进行幅度比较任务时的年龄和CGG重复调制性能，当前研究的结果似乎表明女性fXPC可能保留了基本的心理功能。
A previous study reported preliminary results of enhanced processing of simple visual information in the form of faster reaction times, in female fragile X premutation carriers (fXPCs). In this study, we assessed manual and oral motor reaction times in 30 female fXPCs and 20 neurotypical (NT) controls. Participants completed two versions of the reaction time task; one version required a manual motor response and the other version required an oral motor response. Results revealed that the female fXPCs displayed faster reaction times for both manual and oral motor responses relative to NT controls. Molecular measures including CGG repeat length, FMR1 mRNA levels, and age were not associated with performance in either group. Given previously reported age and CGG repeat modulated performance on a magnitude comparison task in this same group of premutation carriers, results from the current study seem to suggest that female fXPCs may have spared basic psychomotor functionality.