IL12B rs6887695 polymorphism and interaction with alcohol intake in the risk of ulcerative colitis in Japan.
IL12B rs6887695 polymorphism and interaction with alcohol intake in the risk of ulcerative colitis in Japan.
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DOI：
10.1016/j.cyto.2022.155901
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发表时间：
2022-05
期刊：
影响因子：
3.8
通讯作者：
Y. Miyake;Keiko Tanaka;C. Nagata;S. Furukawa;A. Andoh;T. Yokoyama;Naoki Yoshimura;Kenichiro Mori;T. Ninomiya;Y. Yamamoto;E. Takeshita;Y. Ikeda;Mitsuru Saito;Katsuhisa Ohashi;H. Imaeda;K. Kakimoto;K. Higuchi;Hiroaki Nunoi;Yuji Mizukami;Seiyuu Suzuki;S. Hiraoka;Hiroyuki Okada;Keitarou Kawasaki;Masaaki Higashiyama;R. Hokari;Hiromasa Miura;T. Miyake;T. Kumagi;Hiromasa Kato;N. Hato;K. Sayama;Y. Hiasa
中科院分区：
文献类型：
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作者：
Y. Miyake;Keiko Tanaka;C. Nagata;S. Furukawa;A. Andoh;T. Yokoyama;Naoki Yoshimura;Kenichiro Mori;T. Ninomiya;Y. Yamamoto;E. Takeshita;Y. Ikeda;Mitsuru Saito;Katsuhisa Ohashi;H. Imaeda;K. Kakimoto;K. Higuchi;Hiroaki Nunoi;Yuji Mizukami;Seiyuu Suzuki;S. Hiraoka;Hiroyuki Okada;Keitarou Kawasaki;Masaaki Higashiyama;R. Hokari;Hiromasa Miura;T. Miyake;T. Kumagi;Hiromasa Kato;N. Hato;K. Sayama;Y. Hiasa
背景白细胞介素（IL）-23/Th17通路在溃疡性结肠炎（UC）发病中起重要作用。IL-12 p40亚基由IL-12 B基因编码，由IL-23和IL-12共享。目前的病例对照研究调查的关联betweenIL 12 BSNPs rs6887695和UC risk.MethodsThere是384例在4年内的UC诊断和661名对照谁入组。对性别、年龄、吸烟包年数、饮酒量、阑尾炎史、UC家族史、教育水平和体重指数进行了调整。结果与CC基因型相比，GGIL 12 BSNP rs6887695基因型受试者患UC的风险显著增加（校正比值比[AOR]，1.60; 95%置信区间[CI]，1.08-2.36）。使用加性和隐性模型，这种正相关性也很显著（AOR，1.25; 95%CI，1.03-1.52; AOR，1.50; 95%CI，1.08-2.09）。在CC基因型人群中，饮酒量与UC发病风险呈负相关，而在至少有一个G等位基因的人群中，饮酒量与UC发病风险无显著相关性（Pfor交互作用= 0.0008）。饮酒的影响可能依赖于rs6887695。
BackgroundThe interleukin (IL)-23/Th17 pathway plays a critical role in ulcerative colitis (UC). The IL-12p40 subunit, which is shared by IL-23 and IL-12, is encoded by theIL12Bgene. The current case-control study investigated the association betweenIL12BSNP rs6887695 and the UC risk.MethodsThere were 384 cases within 4 years of UC diagnosis and 661 controls who were enrolled. Adjustments were made for sex, age, pack-years of smoking, alcohol consumption, history of appendicitis, family history of UC, education level, and body mass index.ResultsSubjects with the GGIL12BSNP rs6887695 genotype had a significantly increased risk of UC compared with those with the CC genotype (adjusted odds ratio [AOR], 1.60; 95% confidence interval [CI], 1.08–2.36). This positive association was also significant using the additive and recessive models (AOR, 1.25; 95% CI, 1.03–1.52; AOR, 1.50; 95% CI, 1.08–2.09, respectively). An independent inverse relationship was observed between ever alcohol consumption and the UC risk in those with the CC genotype while no significant association was found in those with at least one G allele (Pfor interaction = 0.0008).ConclusionsIL12BSNP rs6887695 was significantly associated with UC. The influence of alcohol consumption might rely on rs6887695.