Different functional reorganization of motor cortex after transfer of the contralateral C7 to different recipient nerves in young rats with total brachial plexus root avulsion
Different functional reorganization of motor cortex after transfer of the contralateral C7 to different recipient nerves in young rats with total brachial plexus root avulsion
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DOI：
10.1016/j.neulet.2012.10.047
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发表时间：
2012-12-07
影响因子：
2.5
通讯作者：
Gu, Yu-dong
中科院分区：
文献类型：
--
作者：
Pan, Feng;Wei, Hai-feng;Gu, Yu-dong
临床上，健侧C7移位用于臂丛神经损伤的神经重建。术后供肢的同步运动值得注意。本研究研究了不同的受体神经在此手术后是否会影响运动皮质的跨大脑功能重组。将90只幼年臂丛神经根性撕脱伤大鼠分为健侧C7移位至上干前支、肌皮神经与正中神经、正中神经移位1~3组。术后1.5个月、3个月、6个月、9个月、12个月分别用皮质内微刺激测定双侧运动皮质前肢前肢代表部位的数目。9个月时，第1组6只大鼠中有4只完成了对侧C7神经支配的跨大脑皮质神经重组，第2组6只大鼠中有1只完成了跨大脑皮质神经重建，第3组中没有一只大鼠；12个月时，第1组6只大鼠中有5只完成了跨大脑皮质神经重组，第2组和3组各6只大鼠中有4只完成了这一重组。Logistic回归分析显示，第1组的跨裂重组率是第3组的12.19倍(95%CI为0.006~0.651，p=0.032)。在12个月时，3组后肢代表侵犯健侧原有前肢代表的点数显著多于2组(t=9.5，p
Clinically, contralateral C7 transfer is used for nerve reconstruction in brachial plexus injuries. Postoperatively, synchronous motions at the donor limb are noteworthy. This study studied if different recipient nerves influenced transhemispheric functional reorganization of motor cortex after this procedure. 90 young rats with total root avulsion of the brachial plexus were divided into groups 1-3 of contralateral C7 transfer to anterior division of the upper trunk, to both the musculocutaneous and median nerves, and to the median nerve, respectively. After reinnervation of target muscles, number of sites for forelimb representations in bilateral motor cortices was determined by intracortical microstimulation at 1.5, 3, 6, 9, and 12 months postoperatively. At nine months, transhemispheric reorganization of nerves neurotized by contralateral C7 was fulfilled in four of six rats in group 1, one of six in group 2 and none in group 3, respectively; at 12 months, that was fulfilled in five of six in group 1, four of six in groups 2 and 3, respectively. Logistic regression analysis showed that rate of fulfilled transhemispheric reorganization in group 1 was 12.19 times that in group 3 (95% Cl 0.006-0.651, p=0.032). At 12 months, number of sites for hindlimb representations which had encroached upon original forelimb representations on the uninjured side was statistically more in group 3 than in group 2 (t=9.5, p