Combined Therapy Planning, Real-Time Monitoring, and Low Intensity Focused Ultrasound Treatment Using a Diagnostic Imaging Array.
Combined Therapy Planning, Real-Time Monitoring, and Low Intensity Focused Ultrasound Treatment Using a Diagnostic Imaging Array.
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基于诊断成像阵列的联合治疗方案规划、实时监测与低强度聚焦超声治疗
DOI：
10.1109/tmi.2021.3140176
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发表时间：
2022-06
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
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作者：
低强度聚焦超声（FUS）治疗使用低强度聚焦超声波，通常与微泡组合，以非侵入性地诱导各种治疗效果。FUS治疗需要治疗前规划和治疗期间的实时监测，以确保FUS射束正确靶向所需的组织区域。为了促进更精简的FUS治疗，我们提出了一个系统，治疗前规划，实时FUS束可视化，低强度FUS治疗使用一个单一的诊断成像阵列。通过手动分割成像阵列捕获的B模式图像并基于用户输入的感兴趣区域计算治疗的超声处理模式来完成治疗计划。对于实时监测，成像阵列发射可视化脉冲，该可视化脉冲被聚焦到与FUS治疗波束相同的位置，并且来自该脉冲的超声反向散射被用于重建FUS波束的强度场。在模拟FUS治疗的同时，在组织模拟体模和大鼠体内肿瘤中证明了治疗计划和射束监测技术。来自成像阵列的FUS脉冲以0.78的MI被激发，这表明该阵列可用于实施涉及微泡激活的选定低强度FUS治疗。
Low intensity focused ultrasound (FUS) therapies use low intensity focused ultrasound waves, typically in combination with microbubbles, to non-invasively induce a variety of therapeutic effects. FUS therapies require pre-therapy planning and real-time monitoring during treatment to ensure the FUS beam is correctly targeted to the desired tissue region. To facilitate more streamlined FUS treatments, we present a system for pre-therapy planning, real-time FUS beam visualization, and low intensity FUS treatment using a single diagnostic imaging array. Therapy planning was accomplished by manually segmenting a B-mode image captured by the imaging array and calculating a sonication pattern for the treatment based on the user-input region of interest. For real-time monitoring, the imaging array transmitted a visualization pulse which was focused to the same location as the FUS therapy beam and ultrasonic backscatter from this pulse was used to reconstruct the intensity field of the FUS beam. The therapy planning and beam monitoring techniques were demonstrated in a tissue-mimicking phantom and in a rat tumor in vivo while a mock FUS treatment was carried out. The FUS pulse from the imaging array was excited with an MI of 0.78, which suggests that the array could be used to administer select low intensity FUS treatments involving microbubble activation.
DOI：
10.7863/ultra.32.9.1535
发表时间：
2013-09
期刊：
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
影响因子：
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作者：
Gauthier M;King DA;O'Brien WD Jr
通讯作者：
O'Brien WD Jr