Demographic and Clinical Factors Associated with Persistent Symptoms after West Nile Virus Infection
Demographic and Clinical Factors Associated with Persistent Symptoms after West Nile Virus Infection
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DOI：
10.4269/ajtmh.2010.09-0717
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发表时间：
2010-11-01
影响因子：
3.3
通讯作者：
Rinaldo, Charles R.
中科院分区：
文献类型：
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作者：
Cook, Robert L.;Xu, Xiaohui;Rinaldo, Charles R.
西尼罗河病毒（WNV）感染者的预后各不相同，但与持续症状相关的最重要因素尚不清楚。2008年完成了一项调查，平均诊断后7 - 7个月，我们确定了214人的最常见症状的人口学和临床特征之间的关系。感染6个月后，53%的人报告了一种或多种持续症状，包括疲劳肌肉疼痛活动减少，记忆困难和难以集中注意力患有神经侵入性疾病的高血压或糖尿病的人更有可能报告持续症状，而年龄，性别和感染时间与持续症状无关。结论：大多数人持续症状持续超过6个月有症状的西尼罗河病毒感染后需要改进预防和治疗策略
Prognosis varies among persons with West Nile virus (WNV) infection but the most important factors associated with persistent symptoms are not clear In this cross sectional study 265 persons with symptomatic WNV infection during 2006-2008 completed a survey a mean of 7 7 months after diagnosis We determined the association of demo graphic and clinical characteristics to the most common symptoms Of 214 persons infected 6 months, 53% reported one or more persistent symptoms, including fatigue muscle aches decreased activity, difficulty with memory, and difficulty concentrating Persons with neuroinvasive disease hypertension or diabetes were significantly more likely to report persistent symptoms, whereas age, sex and time since infection were not associated with persistent symptoms In conclusion persistent symptoms persisted in most persons for more than six months after symptomatic WNV infection Improved strategies for prevention and treatment are needed