Caveolin-1 as a potential high-risk prostate cancer biomarker
Caveolin-1 as a potential high-risk prostate cancer biomarker
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DOI：
10.3892/or.2011.1587
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发表时间：
2012-03-01
期刊：
影响因子：
4.2
通讯作者：
Masarik, Michal
中科院分区：
文献类型：
--
作者：
Gumulec, Jaromir;Sochor, Jiri;Masarik, Michal
目前的前列腺癌诊断技术不能有效地区分前列腺癌的潜伏期和低危型与高危和显性前列腺癌。小窝蛋白-1(Cav-1)除具有其他功能外，还在细胞转化和肿瘤发生过程中发挥重要作用。此外，Cav-1还参与肿瘤的转移过程。研究还表明，Cav-1的表达在氧化应激等应激条件下被诱导。本研究的重点是确定侵袭性(高级别)前列腺癌的预后标志物。我们测定了97例前列腺癌患者(82例)和15例正常对照(对照组)的血清CAV-1和血清抗氧化性标志物谷胱甘肽(GSH)、2，2-二苯基-1-苦基肼(DPPH)、Trolox当量抗氧化力(TEAC)、铁还原抗氧化力(FRAP)、N，N-二甲基-1，4-二氨基苯(DMPD)、自由基法(Frk)和过氧化蓝铬(Cro)。我们发现患者和对照组的血清Cav-1水平没有显著差异(癌症组为5.69 ng/ml，对照组为5.42 ng/ml)。然而，我们发现一个显著的(p
Current diagnostic techniques of prostate cancer cannot efficiently distinguish the latent and low-risk forms from the high-risk significant forms of prostate cancer. Caveolin-1 (Cav-1), except other functions, plays an important role in cell transformation and the process of tumorigenesis. Furthermore, Cav-1 is involved in metastatic processes. It has also been shown that Cav-1 expression is induced under stress conditions, such as oxidative stress. The present study focused on the determination of prognostic markers of aggressive (high-grade) forms of prostate cancer. We determined serum Cav-1 and serum markers of antioxidant activity-glutathione (GSH), 2,2-diphenyl-1-picrylhydrazyl (DPPH), Trolox equivalent antioxidant capacity (TEAC), ferric-reducing antioxidant power (FRAP), N,N-dimethyl-1,4-diaminobenzene (DMPD), free radicals method (FRK) and blue chromium peroxide (Cro) in 97 serum samples (82 prostate cancer patients and 15 controls). We found insignificant differences in Cav-1 between the sera of patients and controls (5.69 in the cancer group vs. 5.42 ng/ml in the control group). However, we found a significant (p