The continuous glucose monitoring system is useful for detecting unrecognized hypoglycemias in patients with type 1 and type 2 diabetes but is not better than frequent capillary glucose measurements for improving metabolic control
The continuous glucose monitoring system is useful for detecting unrecognized hypoglycemias in patients with type 1 and type 2 diabetes but is not better than frequent capillary glucose measurements for improving metabolic control
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DOI：
10.2337/diacare.26.4.1153
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发表时间：
2003-04-01
期刊：
影响因子：
16.2
通讯作者：
Novials, A
中科院分区：
文献类型：
--
作者：
Chico, A;Vidal-Ríos, P;Novials, A
目的 - 评估连续葡萄糖监测系统（CGM；最小化，Sylmar，CA）是否有助于研究I型和2型糖尿病患者中未识别的低血糖的发生率，以及改善I型糖尿病患者的代谢控制。研究方法 - 使用CGMS总共监测70名糖尿病患者（40型I型和30型受试者）。注册了未识别的低血糖症的数量。此外，使用密集的毛细血管葡萄糖测量结果将40名I型糖尿病患者与从CGMS获得的信息进行了修改的40例I型糖尿病患者。 HBA（1C）水平是在监测期之前和3个月后测量的。分子 - CGMS在62.5％的I型糖尿病患者中检测到未识别的低血糖，在2型糖尿病患者中的46.6％中。我们发现所有活动中有73.7％发生在晚上。在用CGM监测的I型糖尿病患者组中，HBA（1C）浓度显着降低（从8.3 +/- 1.6到7.5 +/- 1.2％，P <0.01）和对照组（从8.0 +/- 1.4至7.5 +/- 0.8％，p <0.01）。在开始连续皮下胰岛素输注疗法的患者的亚组中观察到最大的减少，无论是在CGMS-核心和对照组中（从9.4 +/- 2到7.2 +/- 1.4％，从8.1 +/- 1.4％到7.1 +/- 1.8至7.1 +/- 0.6％）.conconclusions -CGM可用于检测I型和2型中未识别的低血糖糖尿病患者；但是，无论治疗方案如何，它都不比标准毛细管葡萄糖测量值改善对I型糖尿病患者的代谢控制。
OBJECTIVE - To evaluate whether the continuous glucose monitoring system (CGMS; MiniMed, Sylmar, CA) is useful for investigating the incidence of unrecognized hypoglycemias in type I and type 2 diabetic patients and for improving metabolic control in type I diabetic patients.RESEARCH DESIGN AND METHODS - A total of 70 diabetic subjects (40 type I and 30 type 2 subjects) were monitored using the CGMS. The number of unrecognized hypoglycemias was registered. Furthermore, the 40 type I diabetic patients whose treatment was modified in accordance with the information obtained from the CGMS were compared with a control group of 35 different type I diabetic patients using intensive capillary glucose measurements. HbA(1c) levels were measured before the monitoring period and 3 months later.RESULTS - The CGMS detected unrecognized hypoglycemias in 62.5% of the type I diabetic patients and in 46.6% of the type 2 diabetic patients. We found that 73.7% of all events occurred at night. HbA(1c) concentrations decreased significantly in both the group of type I diabetic subjects monitored with the CGMS (from 8.3 +/- 1.6 to 7.5 +/- 1.2%, P < 0.01) and the control group (from 8.0 +/- 1.4 to 7.5 +/- 0.8%, P < 0.01). The greatest reduction was observed in the subgroup of patients who started continuous subcutaneous insulin infusion therapy, both in the CGMS-monitored and control groups (from 9.4 +/- 2 to 7.2 +/- 1.4% and from 8.1 +/- 1.8 to 7.1 +/- 0.6%, respectively).CONCLUSIONS - The CGMS is useful for detecting unrecognized hypoglycemias in type I and type 2 diabetic subjects; however, it is not better than standard capillary glucose measurements for improving metabolic control of type I diabetic subjects, regardless of the therapeutic regimen.