Aspergillus nidulans maintains short telomeres throughout development
Aspergillus nidulans maintains short telomeres throughout development
复制标题
DOI：
10.1093/nar/25.7.1426
复制
发表时间：
1997-04-01
影响因子：
14.9
通讯作者：
Blackburn, EH
中科院分区：
文献类型：
--
作者：
Bhattacharyya, A;Blackburn, EH
我们报告的鉴定和克隆的端粒的丝状真菌，构巢曲霉。我们已经确定了三类克隆染色体末端的端粒相关序列（塔斯）的基础上，并证明端粒重复序列是TTAGGG，在脊椎动物，包括人类，和一些低等真核生物中发现的相同。一类端粒克隆被发现含有内部，变异TAAGGG重复。构巢曲霉端粒长度惊人地短（4-22个重复）。我们证明，端粒长度是非常稳定的，在不同的细胞类型和在改变生长温度，这表明高度调节的长度控制机制。
We report the identification and cloning of the telomeres of the filamentous fungus, Aspergillus nidulans. We have identified three classes of cloned chromosomal ends based on the telomere-associated sequences (TASs) and demonstrated that the telomeric repeat sequence is TTAGGG, identical to that found in vertebrates, including humans, and some lower eukaryotes. One category of telomere clones was found to contain internal, variant TAAGGG repeats. The A.nidulans telomeric tract length is striking ly short (4-22 repeats). We demonstrate that telomere length is remarkably stable in different cell types and at altered growth temperatures, suggesting a highly regulated mechanism for length control.