Thermal, catalytic, regiospecific functionalization of alkanes
Thermal, catalytic, regiospecific functionalization of alkanes
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DOI：
10.1126/science.287.5460.1995
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发表时间：
2000-03-17
期刊：
影响因子：
56.9
通讯作者：
Hartwig, JF
中科院分区：
文献类型：
--
作者：
Chen, HY;Schlecht, S;Hartwig, JF
报道了由过渡金属催化的线性烷烃末端官能化反应生成单一产物。铑络合物Cp*Rh(eta(4)-C6Me6) （Cp*, C5Me5; Me，甲基）在热条件下催化产率高的线性烷基硼烷。这些反应现在允许在热条件下催化，特定区域的烷烃功能化。有机硼烷产品是化学中用途最广泛的合成中间体之一，是醇、胺和其他常见功能化分子的便捷前体。
The formation of a single product from terminal functionalization of linear alkanes from a transition metal-catalyzed reaction is reported. The rhodium complex Cp*Rh(eta(4)-C6Me6) (Cp*, C5Me5; Me, methyl) catalyzes the high-yield formation of linear alkylboranes from commercially available borane reagents under thermal conditions. These reactions now allow catalytic, regiospecific functionalization of alkanes under thermal conditions. The organoborane products are among the most versatile synthetic intermediates in chemistry and serve as convenient precursors to alcohols, amines, and other common classes of functionalized molecules.