MORPHOLOGICAL EVIDENCE OF GAP-JUNCTIONS BETWEEN BONE-CELLS
MORPHOLOGICAL EVIDENCE OF GAP-JUNCTIONS BETWEEN BONE-CELLS
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DOI：
10.1007/bf02409482
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发表时间：
1981-01-01
影响因子：
4.2
通讯作者：
DOTY, SB
中科院分区：
文献类型：
--
作者：
DOTY, SB
细胞膜特化发生在相邻的成骨细胞与成骨细胞和骨细胞之间的接触部位。这些连接在防止材料在骨细胞周围的细胞外移动方面很重要。某些小蛋白绕过成骨细胞群，迅速穿透成骨小管-骨细胞系统。在此，使用了镧胶体作为细胞外标志物；镧很容易渗透到骨细胞连接和骨的细胞外间隙。在形态上，这些连接不是紧密或闭塞的结构，而是类似于缝隙连接。这些缝隙连接含有在相邻细胞之间形成细胞间桥梁的元件，但也保持了含有细胞外液的细胞之间2纳米的空间。这些缝隙连接可能在控制或协调整个给定的骨体积中的骨细胞活动方面具有重要的功能。
Cell membrane specializations occur at contact sites between adjacent osteoblasts and osteoblasts and osteocytes. These junctions are important in preventing the extracellular movement of material around bone cells. Certain small proteins circumvent the osteoblast population and rapidly penetrate the canalicular-osteocyte system. Here lanthanum colloid was used as an extracellular marker; the lanthanum readily penetrated the bone cell junctions and the extracellular space of bone. Morphologically, these junctions were not tight or occluding structures but resembled gap junctions. These gap junctions contained elements which formed intercellular bridges between adjacent cells but also maintained a 2-nm space between cells that contained extracellular fluid. These gap junctions may have an important function in the control or coordination of bone cell activity throughout a given bone volume.