Analysis of illicit carfentanil: Emergence of the death dragon
Analysis of illicit carfentanil: Emergence of the death dragon
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DOI：
10.1016/j.forc.2017.02.003
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发表时间：
2017-03-01
影响因子：
2.7
通讯作者：
Guest, Elizabeth M.
中科院分区：
文献类型：
--
作者：
Casale, John F.;Mallette, Jennifer R.;Guest, Elizabeth M.
美国目前正处于前所未有的非法芬太尼危机之中。仅去年一年，与芬太尼有关的过量死亡人数就超过了过去60年。目前的危机是多方面的，涉及芬太尼和相关物质的全球供应被走私到美国。非法的卡芬太尼盐酸盐最近进入毒品市场，在美国造成多起过量用药和死亡。迄今为止，已经确认了400多起卡芬太尼病例。卡芬太尼的药效大约是芬太尼的100倍只需要20毫克的材料就能产生致死剂量。由于缺乏已发表的卡芬太尼HCl光谱，我们提供了最近提交给我们实验室的卡芬太尼的三个分析剖面，包括红外光谱，核磁共振光谱，气相色谱-质谱，同位素比质谱，以及通过气相色谱-火焰电离检测的定量测定。三份申报材料分别含有0.62%、1.87%和0.31%盐酸卡芬太尼。每件展品还含有芬太尼相关物质（芬太尼或2-呋喃基芬太尼）。在两个展品中，乙酰卡芬太尼被定性为杂质。两件展品的同位素分析表明它们是密切相关的。Elsevier B.V.出版
The United States is currently in the midst of an unprecedented illicit fentanyl crisis. In the last year alone there have been more recent fentanyl-related overdose deaths than in the previous 60 years. The current crisis is multi-faceted and involves a global supply of fentanyl and related substances being smuggled into the United States. Illicit carfentanil hydrochloride has recently entered the drug market causing multiple overdoses and deaths across the U.S. To date, over 400 confirmed carfentanil cases have been identified. Carfentanil is approximately 100 times more potent that fentanyl with only 20 mu g of material required to produce a lethal dose. Due to a lack of published spectra for carfentanil HCl, analytical profiles are provided for three recent carfentanil submissions to our laboratory which include infrared spectroscopy, nuclear magnetic resonance spectroscopy, gas chromatography-mass spectrometry, isotope ratio mass spectrometry, and quantitative determination via gas chromatography-flame ionization detection. The three submissions were determined to contain 0.62%, 1.87%, and 0.31% carfentanil HCl, respectively. Each exhibit also contained a fentanyl-related substance (fentanyl or 2-furanylfentanyl). Acetylcarfentanil was characterized as an impurity in two exhibits. Isotopic analyses of two exhibits suggest they are intimately related. Published by Elsevier B.V.