The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
The future of cancer treatment: immunomodulation, CARs and combination immunotherapy.
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DOI：
10.1038/nrclinonc.2016.25
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Wolchok JD
中科院分区：
文献类型：
--
作者：
Khalil DN;Smith EL;Brentjens RJ;Wolchok JD
在过去的十年中，使用单克隆抗体（mAb）和过继细胞疗法通过调节免疫反应来治疗癌症的进展已经导致晚期肿瘤患者出现前所未有的反应，否则这些反应将是致命的。迄今为止，三种免疫检查点阻断mAb已在美国获批用于治疗几种类型的癌症患者，未来数月和数年将有更多患者受益于免疫调节mAb治疗。同时，过继转移的遗传修饰的淋巴细胞治疗血液系统恶性肿瘤患者已经取得了显着的结果，我们预计，这种方法将迅速成为越来越多的患者的护理标准。在这篇综述中，我们重点介绍了免疫疗法的最新进展，并讨论了它在未来癌症治疗中的作用，包括推荐测试组合策略和“装甲”CAR T细胞的设置。
In the past decade, advances in the use of monoclonal antibodies (mAbs) and adoptive cellular therapy to treat cancer by modulating the immune response have led to unprecedented responses in patients with advanced-stage tumours that would otherwise have been fatal. To date, three immune-checkpoint-blocking mAbs have been approved in the USA for the treatment of patients with several types of cancer, and more patients will benefit from immunomodulatory mAb therapy in the months and years ahead. Concurrently, the adoptive transfer of genetically modified lymphocytes to treat patients with haematological malignancies has yielded dramatic results, and we anticipate that this approach will rapidly become the standard of care for an increasing number of patients. In this Review, we highlight the latest advances in immunotherapy and discuss the role that it will have in the future of cancer treatment, including settings for which testing combination strategies and ‘armoured’ CAR T cells are recommended.
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影响因子：
15.3
作者：
Bonifaz, L;Bonnyay, D;Mahnke, K;Rivera, M;Nussenzweig, MC;Steinman, RM
通讯作者：
Steinman, RM
影响因子：
5.4
作者：
Baumann, R;Yousefi, S;Simon, HU
通讯作者：
Simon, HU
影响因子：
4.4
作者：
Ankri, Chen;Shamalov, Katerina;Cohen, Cyrille J.
通讯作者：
Cohen, Cyrille J.
影响因子：
30.5
作者：
Blackburn, Shawn D.;Shin, Haina;Haining, W. Nicholas;Zou, Tao;Workman, Creg J.;Polley, Antonio;Betts, Michael R.;Freeman, Gordon J.;Vignali, Dario A. A.;Wherry, E. John
通讯作者：
Wherry, E. John
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM