The association between self-reported varenicline adherence and varenicline blood levels in a sample of cancer patients receiving treatment for tobacco dependence.
The association between self-reported varenicline adherence and varenicline blood levels in a sample of cancer patients receiving treatment for tobacco dependence.
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DOI：
10.1016/j.abrep.2018.06.006
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发表时间：
2018-12-01
影响因子：
--
通讯作者：
Schnoll, Robert
中科院分区：
文献类型：
--
作者：
Crawford, Grace;Jao, Nancy;Schnoll, Robert
简介：吸烟者使用伐尼克兰成功戒烟的程度与他们对药物治疗方案的依从性密切相关。因此，测量伐尼克兰依从性以识别需要额外干预的吸烟者是当务之急。然而，很少有研究以依从性的生物学评估作为参考来检验自我报告的伐尼克兰依从性的有效性。目前还没有研究在试图戒烟的癌症患者中检查过这个问题，考虑到他们的医疗合并症，他们可能表现出独特的依从模式。 方法：本研究使用了 76 名接受伐尼克兰治疗的癌症患者的数据，并提供了自我报告的伐尼克兰依从性数据（药丸计数）和血液样本，以确定开始使用伐尼克兰后 4 周的伐尼克兰代谢物。 结果：血浆伐尼克兰的受试者工作特征 (ROC) 曲线分析水平表明，4ng/ml 是区分依从性与显着性（p's
INTRODUCTION: The degree to which smokers quit successfully with varenicline is strongly associated with their adherence to the medication regimen. Thus, measuring varenicline adherence to identify smokers needing additional intervention is a priority. Few studies, however, have examined the validity of self-reported varenicline adherence, using a biological assessment of adherence as a reference. No study has examined this issue among cancer patients trying to quit smoking, who may show unique patterns of adherence given their medical comorbidity.METHODS: This study used data from 76 cancer patients who received varenicline and provided self-reported varenicline adherence data (pill count) and a blood sample to determine varenicline metabolites 4 weeks after initiating varenicline.RESULTS: Receiver operating characteristic (ROC) curve analyses of plasma varenicline levels showed that 4 ng/ml was the optimal cut-point for differentiating adherence with significant (p's