An overview of the potassium channel family.
An overview of the potassium channel family.
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DOI：
10.1186/gb-2000-1-4-reviews0004
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发表时间：
2000
期刊：
影响因子：
12.3
通讯作者：
中科院分区：
文献类型：
--
作者：
钾通道是一种四聚体完整的膜蛋白，形成水孔，K+可以通过这些孔流动，几乎在所有生物中都存在；人类、果蝇和秀丽线虫的基因组中都含有30-100个K+通道基因。细菌K+通道的结构、与其他通道的序列比较和电生理测量使人们能够对许多其他通道得出关于门控和离子流机制的结论。
Potassium channels, tetrameric integral membrane proteins that form aqueous pores through which K+ can flow, are found in virtually all organisms; the genomes of humans, Drosophila, and Caenorhabditis elegans contain 30-100 K+ channel genes each. The structure of a bacterial K+ channel, sequence comparisons with other channels and electrophysiological measurements have enabled conclusions about the mechanism of gating and ion flow to be drawn for many other channels.