Update on Pruritic Mechanisms of Hypertrophic Scars in Postburn Patients: The Potential Role of Opioids and Their Receptors
Update on Pruritic Mechanisms of Hypertrophic Scars in Postburn Patients: The Potential Role of Opioids and Their Receptors
复制标题
烧伤后患者肥厚性疤痕瘙痒机制的最新进展：阿片类药物及其受体的潜在作用
DOI：
10.1097/bcr.0b013e3182223c32
复制
发表时间：
2011-07-01
影响因子：
1.4
通讯作者：
Fu, Xiao-Bing
中科院分区：
文献类型：
--
作者：
Cheng, Biao;Liu, Hong-Wei;Fu, Xiao-Bing
虽然疤痕中的瘙痒(或瘙痒)是一种非常常见和令人痛苦的症状，并日益被认为是烧伤康复的一个重要障碍，但这种症状的确切机制尚未阐明；因此，尚未建立可靠的治疗方法。最近的发现表明，炎症性皮肤病引起的瘙痒可以通过抗组胺药物来减少，但组胺拮抗剂不能阻止所有类型的瘙痒(如神经性瘙痒)。这表明瘙痒存在组胺非依赖性途径。瘙痒或瘙痒也可以由阿片受体的直接激活引起，阿片受体是最近在皮肤中发现的。本文旨在评估关于阿片类药物在烧伤后增生性瘢痕瘙痒发生中的作用的知识现状。为此，作者回顾了相关文献，并提供了一些临床数据。作者希望这篇综述将为未来阐明瘙痒的机制和治疗的研究奠定基础。
Although itching (or pruritus) in a scar is a very common and distressing symptom and is increasingly being recognized as a significant obstacle in burn rehabilitation, the exact mechanisms underlying this symptom have not been elucidated; hence, a reliable therapy has not been established. Recent findings have suggested that itching caused by inflammatory dermatosis can be reduced by antihistamines, but histamine antagonists cannot block all types of pruritus (eg, neuropathic itch). This indicates the presence of a histamine-independent pathway for itch. Itch or pruritus may also be evoked by direct activation of opioid receptors, which have recently been identified in the skin. This article aims to assess the current state of knowledge regarding the role of opioids in the generation of itch in hypertrophic scars in postburn patients. To this end, the authors have reviewed the relevant literature and present some clinical data. The authors hope that this review will form the basis for future research to elucidate the mechanism and treatment of itch.