Isostructural self-assembly of 2′-deoxyguanosine derivatives in aqueous and organic media
Isostructural self-assembly of 2′-deoxyguanosine derivatives in aqueous and organic media
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DOI：
10.1021/ja8039019
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发表时间：
2008-08-13
影响因子：
15
通讯作者：
Rivera, Jose M.
中科院分区：
文献类型：
--
作者：
Garcia-Arriaga, Marilyn;Hobley, Gerard;Rivera, Jose M.
我们报道了亲水性8-（m-乙酰苯基）-2'-脱氧鸟苷（mAG）衍生物在水介质中自组装成离散且热稳定的十六元超分子。我们证明了这种十六进制体与有机介质中相关的亲脂衍生物形成的十六进制体是同结构的。这个mAG片段代表了一个罕见的小分子识别基序的例子，它能够在有机和水介质中以相同的结构和高保真度组装。
We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media.