Prognostic factors for the survival of patients with papillary renal cell carcinoma:: Meaning of histological typing and multifocality
Prognostic factors for the survival of patients with papillary renal cell carcinoma:: Meaning of histological typing and multifocality
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DOI：
10.1097/01.ju.0000081122.57148.ec
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发表时间：
2003-09-01
影响因子：
6.6
通讯作者：
Dufour, B
中科院分区：
文献类型：
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作者：
Méjean, A;Hopirtean, V;Dufour, B
目的：我们确定了影响乳头状肾细胞癌（PRCC）1型（PRCC 1）和2型（PRCC 2）的预后因素。材料和方法：1985年至1998年，759例肾细胞癌患者接受手术治疗，其中88例（11.6%），包括69名男性和19名女性，平均年龄61.8岁（范围21.3至85.9）谁有PRCC。多灶性定义为2个或更多肿瘤间隔10 mm或更大。小嗜碱性细胞定义PRCC 1，大嗜酸性细胞定义PRCC 2。79例病例的平均随访时间为71.1个月（范围1至196.6个月）。结果：88例患者行根治性肾切除术（65例）或保守性手术（28例，其中选择性手术17例，必要性手术11例）。平均肿瘤大小为62 mm（范围10 - 190），41%的病变为多灶性，与PRCC大小、分期、分级或类型无关。将56例PRCC 1（63.6%）与32例PRCC 2（36.4%）进行比较，结果显示PRCC 2级别和分期显著更高（分别为p = 0.024和0.025）。共有51例患者（64.6%）保持无复发和无进展。2例（2.5%）仅在保守性手术后局部复发。在26例死亡中，15例（4例PRCC 1和11例PRCC 2）与肿瘤相关。平均生存期为26.6个月（范围1至112.5）。总的10年生存率为73%，PRCC 1和PRCC 2的10年生存率分别为80%和59%（p
Purpose: We identified prognostic factors of papillary renal cell carcinoma (PRCC) types 1 (PRCC1) and 2 (PRCC2).Materials and Methods: Between 1985 and 1998, 759 patients underwent surgery for renal cell carcinoma, of whom 88 (11.6%), including 69 males and 19 females with a mean age of 61.8 years (range 21.3 to 85.9) who had PRCC. Multifocality was defined as 2 or greater tumors separated by 10 mm or greater. Small basophilic cells defined PRCC1 and large eosinophilic cells defined PRCC2. Mean followup in 79 cases was 71.1 months (range 1 to 196.6). Survival rates were calculated and statistical analyses were done.Results: The 88 patients underwent radical nephrectomy (65) or conservative surgery (28, that is elective in 17 and imperative in 11). Mean tumor size was 62 mm (range 10 to 190) and 41% of lesions were multifocal, independent of PRCC size, stage, grade or type. Comparing the 56 PRCC1s (63.6%) to the 32 PRCC2s (36.4%) showed that PRCC2 grade and stage were significantly higher (p = 0.024 and 0.025, respectively). A total of 51 patients (64.6%) remained relapse-free and progression-free. Local relapses occurred only after imperative conservative surgery in 2 cases (2.5%). Of the 26 deaths 15 (4 PRCC 1 and 11 PRCC 2) were tumor associated. Mean survival was 26.6 months (range 1 to 112.5). The overall 10-year survival rate was 73% with PRCC1 and PRCC2 10-year rates of 80% and 59%, respectively (p