C-anaphases: a mitotic variant.
C-anaphases: a mitotic variant.
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C-后期：有丝分裂变体。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
H. Rivera
中科院分区：
文献类型：
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作者：
M. G. Domínguez;H. Rivera
为了评估秋水仙素阻滞淋巴细胞培养中C-后期的频率，作者研究了100例患者，分为四组：自然流产（n = 17），低生育力（n = 12），非整倍体（n = 18）和杂项（n = 53）。对至少300个有丝分裂G带细胞进行个体评分。在12个个体中未观察到C-后期;在87个个体中，范围为1-7，众数为2，平均值为2.14;其余个体在330个细胞中有19个C-后期（5.7%）。经统计学分析，两组间无显著性差异（p > 0.05）。这些数据沿着先前的研究表明，通常大多数个体在习惯性淋巴细胞培养中具有<或= 3%的C-后期。此外，存在一种常染色体显性形式，其中具有该性状的个体具有> 5%的具有这种有丝分裂构型的细胞。我们的结论是，无论是低频率的常见和高频率的熟悉的形式是有丝分裂的变种没有病理意义。
In order to assess the frequency of C-anaphases in colchicine-arrested lymphocyte cultures, the authors studied 100 patients classified in four groups: spontaneous abortion (n = 17), subfertility (n = 12), aneuploidy (n = 18) and miscellaneous (n = 53). At least 300 mitotic G-banded cells were scored by individual. In 12 individuals no C-anaphases were observed; in 87 individuals the range was 1-7 with a mode of 2 and a mean of 2.14; the remaining individual had 19 C-anaphases in 330 cells (5.7%). The statistical analysis did not show significant differences between the groups (p > 0.05). These data along with previous studies indicate that normally most individuals have < or = 3% of C-anaphases in habitual lymphocyte cultures. Moreover, there exists an autosomal dominant form in which individuals with the trait have > 5% of the cells with such mitotic configurations. We conclude that both the low frequency common and the high frequency familiar forms are mitotic variants without pathological significance.