Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis.
Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis.
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DOI：
10.1136/bjophthalmol-2015-307223
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Rudnicka AR
中科院分区：
文献类型：
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作者：
Kapetanakis VV;Chan MP;Foster PJ;Cook DG;Owen CG;Rudnicka AR
对已发表的基于人群的调查进行系统性综述，以检查原发性开角型青光眼（POAG）患病率与人口统计学因素之间的关系。文献检索确定了对POAG患病率进行定量估计的基于人群的研究（截至2014年10月）。POAG的对数优势的多水平二项逻辑回归用于检查年龄和性别在不同地理和种族人群中的影响，调整研究设计因素。纳入了81项研究（37个国家，216214例受试者，5266例POAG病例）。 黑人人群POAG患病率最高，60岁时为5.2%（95%可信区间（CrI）3.7%，7.2%），80岁时上升至12.2%（95%可信区间（CrI）8.9%至16.6%）。 每10岁POAG患病率的增加在西班牙裔（2.31，95% CrI 2.12，2.52）和白色人群（1.99，95% CrI 1.86，2.12）中最大，在东亚和南亚人群中最低（分别为1.48，95% CrI 1.39，1.57; 1.56，95% CrI 1.31，1.88）。男性比女性更容易患POAG（1.30，95%CrI 1.22，1.41）。早期研究中POAG患病率较低，这与青光眼定义中包括眼内压有关。所有受试者视野数据的研究比子集视野数据的研究有更高的POAG患病率。2015年，全球有5750万人（95%CI 46.4 - 7310万）受到POAG的影响，到2020年将增加到6550万人（95%CI 52.8，8320万）。本系统综述提供了对POAG患病率的最精确估计，并显示在人群调查中忽略常规视野评估可能影响病例确定。我们的研究结果将有助于未来的研究和医疗保健计划。
Systematic review of published population based surveys to examine the relationship between primary open angle glaucoma (POAG) prevalence and demographic factors. A literature search identified population-based studies with quantitative estimates of POAG prevalence (to October 2014). Multilevel binomial logistic regression of log-odds of POAG was used to examine the effect of age and gender among populations of different geographical and ethnic origins, adjusting for study design factors. Eighty-one studies were included (37 countries, 216 214 participants, 5266 POAG cases). Black populations showed highest POAG prevalence, with 5.2% (95% credible interval (CrI) 3.7%, 7.2%) at 60 years, rising to 12.2% (95% CrI 8.9% to 16.6%) at 80 years. Increase in POAG prevalence per decade of age was greatest among Hispanics (2.31, 95% CrI 2.12, 2.52) and White populations (1.99, 95% CrI 1.86, 2.12), and lowest in East and South Asians (1.48, 95% CrI 1.39, 1.57; 1.56, 95% CrI 1.31, 1.88, respectively). Men were more likely to have POAG than women (1.30, 95% CrI 1.22, 1.41). Older studies had lower POAG prevalence, which was related to the inclusion of intraocular pressure in the glaucoma definition. Studies with visual field data on all participants had a higher POAG prevalence than those with visual field data on a subset. Globally 57.5 million people (95% CI 46.4 to 73.1 million) were affected by POAG in 2015, rising to 65.5 million (95% CrI 52.8, 83.2 million) by 2020. This systematic review provides the most precise estimates of POAG prevalence and shows omitting routine visual field assessment in population surveys may have affected case ascertainment. Our findings will be useful to future studies and healthcare planning.