Cross-Sex Hormone Treatment and Psychobiological Changes in Transsexual Persons: Two-Year Follow-Up Data
Cross-Sex Hormone Treatment and Psychobiological Changes in Transsexual Persons: Two-Year Follow-Up Data
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DOI：
10.1210/jc.2016-1276
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发表时间：
2016-11-01
影响因子：
5.8
通讯作者：
Maggi, Mario
中科院分区：
文献类型：
--
作者：
Fisher, Alessandra D.;Castellini, Giovanni;Maggi, Mario
内容：到目前为止，有几个研究调查的影响引起的身体变化的跨性别激素治疗（CHT）对心理生物学幸福感的性别焦虑的人（GDs）。目的：本研究的目的是评估是否CHT相关的身体变化影响心理生物学幸福感在GDs.Methods：连续一系列的359 GD被认为是一个横截面部分的研究。此外，在2年随访中对54例GD进行了研究。进行体格检查，包括体重指数、腰围和毛发分布。我们还评估了男性与女性受试者的乳房发育和睾丸体积以及女性与男性的阴蒂长度。要求受试者完成几项心理测量，以评估身体不安、GD和精神病理学水平。结果：（1）与未接受CHT者相比，接受CHT者的GD、躯体不适和抑郁症状的主观水平显著降低，（2）CHT引起的躯体改变与更好的心理适应显著相关;（3）社区卫生服务期间，GD患者的一般精神病理学、抑郁症状和主观GD显著减少，而GD的社会和法律的指标则随时间显著增加; 4）在CHT引起的身体变化中，只有乳房发育和体重指数增加分别对男性对女性受试者和女性对男性受试者的精神病理学降低有显著影响。上述结果支持CHT干预在改善对自己身体的主观感知方面的功效，这部分与客观变化有关。
Context: To date, there are few studies investigating the impact of body changes induced by cross-sex hormonal treatment (CHT) on psychobiological well-being in gender-dysphoric persons (GDs).Objective: The objective of the study was to assess whether CHT-related body changes affect psychobiological well-being in GDs.Methods: A consecutive series of 359 GDs was considered for a cross-sectional section of the study. In addition, 54 GDs were studied in a 2-year follow-up. A physical examination was performed, including body mass index, waist circumference, and hair distribution. We also evaluated breast development and testis volume in male to female subjects and clitoris length in female to male. Subjects were asked to complete several psychometric measures for the assessment of body uneasiness, GD, and psychopathology levels. The evaluation was repeated 2 years prospectively.Results: The following results were found: 1) GDs undergoing CHT reported significantly lower subjective levels of GD, body uneasiness, and depressive symptoms as compared with those without; 2) CHT-induced body modifications were significantly associated with a better psychological adjustment; 3) during CHT, GDs reported a significant reduction of general psychopathology, depressive symptoms, and subjective GD, whereas social and legal indicators of GD showed a significant increase across time; and 4) among body changes induced by CHT, only breast development and increased body mass index had a significant impact on psychopathology reduction across time in male to female subjects and female to male subjects, respectively.Conclusions: The aforementioned results support the efficacy of CHT intervention in improving subjective perception of one's own body, which was partially associated with objective changes.