Proteopathic lesions in the brain of a super-aged chimpanzee (Pan troglodytes)
Proteopathic lesions in the brain of a super-aged chimpanzee (Pan troglodytes)
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DOI：
10.1111/jmp.12530
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发表时间：
2021-06-07
影响因子：
0.7
通讯作者：
Murakami, Tomoaki
中科院分区：
文献类型：
--
作者：
Iwaide, Susumu;Yanai, Tokuma;Murakami, Tomoaki
一只估计68岁的黑猩猩的大脑被检查了，这是迄今为止报道的最古老的黑猩猩。病理学分析显示，除了严重的脑淀粉样血管病和弥漫性斑块外，还形成了轻度tau蛋白阳性神经炎簇和细胞质α-突触核蛋白聚集体，但未观察到缠结病变。
The brain of a chimpanzee estimated to be 68 years old, the oldest reported so far, has been examined. Pathological analyses revealed the formation of mild tau-positive neuritic clusters and cytoplasmic alpha-synuclein aggregates, in addition to severe cerebral amyloid angiopathy and diffuse plaques, but no tangle lesions were observed.