Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population.
Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population.
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DOI：
10.3748/wjg.v16.i28.3578
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发表时间：
2010-07
影响因子：
4.3
通讯作者：
Ying Zeng;Qingmin Sun;Nan-nan Liu;G. Dong;Jie Chen;Li Yang;Bin Wang-
中科院分区：
文献类型：
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作者：
Ying Zeng;Qingmin Sun;Nan-nan Liu;G. Dong;Jie Chen;Li Yang;Bin Wang-
目的探讨前体miR-146 a基因C/G多态性与胃癌发病风险的关系。方法我们采用聚合酶链反应-限制性片段长度多态性方法对608例个体（304例胃癌患者和304例年龄和性别匹配的无癌对照）进行了以医院为基础的病例对照研究。结果病例组与对照组的pre-miR-146 a C/G基因型频率差异有统计学意义（P = 0.037）。与CC基因型携带者相比，变异基因型（GC + GG）受试者患胃癌的风险增加58%（调整OR = 1.58，95%CI：1.11-2.20，P = 0.009）。此外，较高的胃癌风险在年龄≤ 58岁、不吸烟和男性的年轻个体中尤其明显（校正OR = 1.76，95% CI：1.08-2.87，P = 0.024;校正OR = 1.55，95% CI：1.06-2.28，P = 0.025;校正OR = 1.53，95% CI：1.04-2.27，P = 0.033;分别）。结论Pre-miR-146 a基因C/G多态性可能与中国人群胃癌发病风险相关。
AIM To investigate the association between pre-miR-146a C/G polymorphism and gastric cancer risk. METHODS We performed a hospital-based, case-control study using polymerase chain reaction-restriction fragment length polymorphism method in 608 individuals (304 gastric cancer patients and 304 age and sex matched cancer-free controls). RESULTS The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups (P = 0.037). Compared with CC genotype carriers, subjects with the variant genotypes (GC + GG) had a 58% increased risk of gastric cancer (adjusted OR = 1.58, 95% CI: 1.11-2.20, P = 0.009). Moreover, a higher gastric cancer risk was especially evident in younger individuals aged < or =58 years, nonsmokers, and males (adjusted OR = 1.76, 95% CI: 1.08-2.87, P = 0.024; adjusted OR = 1.55, 95% CI: 1.06-2.28, P = 0.025; adjusted OR = 1.53, 95% CI: 1.04-2.27, P = 0.033; respectively). CONCLUSION Pre-miR-146a C/G polymorphism might be associated with an elevated risk of gastric cancer in Chinese population.