Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties
Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties
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DOI：
10.1002/marc.201000341
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发表时间：
2010-09-01
影响因子：
4.6
通讯作者：
Kataoka, Kazunori
中科院分区：
文献类型：
--
作者：
Kumagai, Michiaki;Sarma, Tridib Kumar;Kataoka, Kazunori
高密度聚乙二醇（PEG）包覆的氧化铁-金核壳纳米粒子（AuION）被开发为用于癌症成像的T-2加权磁共振成像（MRI）造影剂。PEG包覆的氧化铁-金核壳纳米粒子（PEG-AuIONs）直径约为25 nm，分布较窄。用C26小鼠结肠腺癌细胞制备的皮下结肠癌模型小鼠的生物分布实验显示PEG-AuION在肿瘤块内的高积累和在肝脏和脾脏中的低非特异性积累，导致对实体瘤的高特异性。静脉注射PEG-AuION后的T-2加权MR图像显示，在用Mia-PaCa-2人胰腺癌细胞制备的原位胰腺癌模型中，肿瘤组织选择性负增强。这些结果表明，PEG-AuION是一种有前途的MRI造影剂，用于诊断恶性肿瘤，包括胰腺癌。
High-density poly(ethylene glycol) (PEG)-coated iron-oxide-gold core-shell nanoparticles (AuIONs) were developed as T-2-weighted magnetic resonance imaging (MRI) contrast agents for cancer imaging. The PEG-coated iron-oxide-gold core-shell nanoparticles (PEG-AuIONs) were approximately 25 nm in diameter with a narrow distribution. Biodistribution experiments in mice bearing a subcutaneous colon cancer model prepared with C26 murine colon adenocarcinoma cells showed high accumulation of the PEG-AuIONs within the tumor mass and low nonspecific accumulation in the liver and spleen, resulting in high specificity to solid tumors. T-2-weighted MR images following intravenous injection of PEG-AuIONs showed selective negative enhancement of tumor tissue in an orthotopic pancreatic cancer model prepared with Mia-PaCa-2 human pancreatic adenocarcinoma cells. These results indicate that PEG-AuIONs are a promising MRI contrast agent for diagnosis of malignant tumors, including pancreatic cancer.