DSC analysis of human plasma in breast cancer patients
DSC analysis of human plasma in breast cancer patients
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DOI：
10.1016/j.tca.2011.06.019
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发表时间：
2011-09-20
影响因子：
3.5
通讯作者：
Lorinczy, Denes
中科院分区：
文献类型：
--
作者：
Zapf, Istvan;Fekecs, Tamas;Lorinczy, Denes
乳腺癌是世界范围内女性癌症死亡的最常见原因，在经济发达国家，其发病率多年来一直在上升。差示扫描量热法（DSC）越来越多地应用于肿瘤学目的，因为它可以用作诊断和监测肿瘤的新方法。目前的研究是用DSC检测乳腺癌患者的液态血浆成分。该研究包括19名不同肿瘤直径（0.5-75 mm）的女性，有或无区域淋巴结转移（0-10个转移性淋巴结）。术前采集患者和健康对照者的外周血，用DSC技术分析血浆成分。根据术后组织学结果评价肿瘤组织的直径和转移淋巴结的数量。在我们的初步研究中，我们观察了乳腺癌患者血浆中的热变化（例如T（m），热焓），我们发现了与肿瘤大小和区域淋巴结浸润程度的相关性。需要进一步的研究来澄清这些关系，但我们的DSC方法的应用提供了一个潜在的工具，乳腺癌患者的早期诊断和监测。(C)2011 Elsevier B. V.保留所有权利。
Breast cancer is the commonest cause of cancer death in women worldwide, and its incidence has been increasing for many years in economically developed countries. Differential scanning calorimetry (DSC) is more and more often applied for oncological purposes, as it could be used as a new method for diagnose and monitoring tumours. In current research liquid plasma components was detected with DSC in breast cancer patients. The study included 19 women with different tumour diameter (0.5-75 mm) and with or without regional lymph node metastases (0-10 metastatic lymph node). Preoperatively peripheral blood samples were collected from the patients and from healthy controls, and plasma components were analysed by DSC technique. The diameter of the tumour tissue and the number of metastatic lymph nodes were evaluated on the basis of postoperative histological results. In our preliminary study we observed thermic changes (e.g. T(m), calorimetric enthalpy) in the blood plasma of breast cancer patients, and we have found correlation with tumour size and with the degree of regional lymph node invasion as well. Further studies are needed to clarify these relationships, but our application of the DSC method has provided a potential tool for the early diagnosis and monitoring of breast cancer patients. (C) 2011 Elsevier B.V. All rights reserved.