ARE MULTIFOCAL MOTOR NEUROPATHY PATIENTS UNDERDIAGNOSED? AN EPIDEMIOLOGICAL SURVEY IN JAPAN
ARE MULTIFOCAL MOTOR NEUROPATHY PATIENTS UNDERDIAGNOSED? AN EPIDEMIOLOGICAL SURVEY IN JAPAN
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DOI：
10.1002/mus.23930
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发表时间：
2014-03-01
期刊：
影响因子：
3.4
通讯作者：
Kaji, Ryuji
中科院分区：
文献类型：
--
作者：
Miyashiro, Ai;Matsui, Naoko;Kaji, Ryuji
简介：我们的目的是对日本的多灶性运动神经病（MMN）患者和肌萎缩侧索硬化（ALS）患者进行流行病学调查。研究方法：在这项回顾性研究中，我们检查了2005年至2009年日本主要神经肌肉中心的46例MMN患者和1，051例ALS患者。诊断基于欧洲神经学会联合会/周围神经学会（EFNS/PNS）和修订的埃尔埃斯科里亚标准。静脉注射免疫球蛋白（IVIg）的有效性也被考虑在MMN的诊断。结果：MMN与ALS患者的比值（0-0.10）在各中心之间存在差异，但大多数集中在0.05。患病率估计为每100，000人中有0.29名MMN患者和6.63名ALS患者。结论：MMN患者的频率约为20例ALS患者中的1例，并且MMN在某些中心可能被诊断不足。肌肉神经49：357-361，2014
Introduction: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers. Muscle Nerve49:357-361, 2014